Enabling Technologies for Personalized and Precision Medicine

被引：231

作者：

Ho, Dean ^{[1
,2
,3
,4
]}

Quake, Stephen R. ^{[5
,6
,7
]}

McCabe, Edward R. B. ^{[8
]}

Chng, Wee Joo ^{[9
,10
]}

Chow, Edward K. ^{[4
,10
]}

Ding, Xianting ^{[11
]}

Gelb, Bruce D. ^{[12
,13
]}

Ginsburg, Geoffrey S. ^{[14
]}

Hassenstab, Jason ^{[15
,16
]}

Ho, Chih-Ming ^{[17
]}

Mobley, William C. ^{[18
]}

Nolan, Garry P. ^{[19
]}

Rosen, Steven T. ^{[20
,21
]}

Tan, Patrick ^{[22
]}

Yen, Yun ^{[23
]}

Zarrinpar, Ali ^{[24
]}

机构：

[1] Natl Univ Singapore, N1 Inst Hlth N1, Singapore, Singapore

[2] Natl Univ Singapore, Inst Digital Med WisDM, Singapore, Singapore

[3] Natl Univ Singapore, Dept Biomed Engn, NUS Engn, Singapore, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore

[5] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA

[7] Chan Zuckerberg Biohub, San Francisco, CA USA

[8] March Dimes Fdn, New York, NY 10022 USA

[9] Natl Univ Hlth Syst, Natl Univ Canc Inst, Dept Haematol & Oncol, Singapore, Singapore

[10] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

[11] Shanghai Jiao Tong Univ, Inst Personalized Med, Shanghai, Peoples R China

[12] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, Dept Pediat, New York, NY 10029 USA

[13] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, Dept Genet & Genom Sci, New York, NY 10029 USA

[14] Duke Univ, Ctr Appl Genom & Precis Med, Durham, NC 27706 USA

[15] Washington Univ, Dept Neurol, St Louis, MO USA

[16] Washington Univ, Psychol & Brain Sci, St Louis, MO USA

[17] Univ Calif Los Angeles, Dept Mech Engn, Los Angeles, CA USA

[18] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[19] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA USA

[20] City Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA

[21] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA USA

[22] Natl Univ Singapore, Duke NUS Med Sch, Singapore, Singapore

[23] Taipei Med Univ, Coll Med Technol, Ctr Canc Translat Res, Taipei Canc Ctr, Taipei, Taiwan

[24] Univ Florida, Dept Surg, Div Transplantat & Hepatobiliary Surg, Gainesville, FL 32611 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2020年 / 38卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CIRCULATING TUMOR-CELLS; LUNG-CANCER PATIENTS; IN-VIVO; GENOMIC MEDICINE; DRUG DEVELOPMENT; DIGITAL HEALTH; OVARIAN-CANCER; THERAPY; OPTIMIZATION; DELIVERY;

D O I：

10.1016/j.tibtech.2019.12.021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.

引用

页码：497 / 518

页数：22

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