Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

被引：446

作者：

Indran, Inthrani R. ^{[1
]}

Tufo, Gregory ^{[2
,3
,4
]}

Pervaiz, Shazib ^{[1
,5
,6
,7
]}

Brenner, Catherine ^{[2
,3
,4
]}

机构：

[1] Natl Univ Singapore, Dept Physiol, Yong Loo Lin Sch Med, Apoptosis ROS & Canc Biol Program, Singapore 117597, Singapore

[2] Univ Paris Sud, F-92290 Chatenay Malabry, France

[3] INSERM, UMR S 769, F-92290 Chatenay Malabry, France

[4] PRES UnivSud Paris, F-92290 Chatenay Malabry, France

[5] Duke NUS Grad Med Sch, Canc & Stem Cell Biol Program, Singapore, Singapore

[6] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117597, Singapore

[7] Singapore MIT Alliance, Singapore, Singapore

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2011年 / 1807卷 / 06期

基金：

英国医学研究理事会;

关键词：

Mitochondrion; Oncogene; Bcl-2; Permeability transition pore; Cell death; Metabolism; PERMEABILITY TRANSITION PORE; BCL-2 FAMILY PROTEINS; CYTOCHROME-C RELEASE; ADENINE-NUCLEOTIDE TRANSLOCASE; EFFICIENTLY INDUCES APOPTOSIS; INTRACELLULAR REDOX STATUS; SMALL-MOLECULE INHIBITOR; TRAIL-INDUCED APOPTOSIS; BH3 MIMETIC ABT-737; MEMBRANE PERMEABILIZATION;

D O I：

10.1016/j.bbabio.2011.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells. This article is part of a Special Issue entitled: Bioenergetics of Cancer. (C) 2011 Published by Elsevier B.V.

引用

页码：735 / 745

页数：11

共 149 条

[1] Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells [J].