Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia

被引：4

作者：

Josephsen, Justin B. ^{[1
]}

Hemmann, Brianna M. ^{[2
]}

Anderson, Connie D. ^{[1
]}

Hemmann, Brett M. ^{[3
]}

Buchanan, Paula M. ^{[4
]}

Williams, Howard L. ^{[5
]}

Lubsch, Lisa M. ^{[5
,6
]}

Hillman, Noah H. ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Dept Pediat, Div Neonatal Perinatal Med, St Louis, MO 63104 USA

[2] Cincinnati Childrens Hosp Med Ctr, Dept Pharm, Cincinnati, OH 45229 USA

[3] Christ Hosp Hlth Network, Dept Pharm, Cincinnati, OH USA

[4] St Louis Univ, Sch Med, Dept Hlth & Clin Outcomes Res, St Louis, MO USA

[5] SSM Hlth Cardinal Glennon Childrens Hosp, Dept Pharm, St Louis, MO USA

[6] Southern Illinois Univ Edwardsville, Sch Pharm, Dept Pharm Practice, Edwardsville, IL USA

来源：

JOURNAL OF PERINATOLOGY | 2022年 / 42卷 / 01期

关键词：

ONSET CIRCULATORY COLLAPSE; LOW-DOSE HYDROCORTISONE; BIRTH-WEIGHT INFANTS; PRETERM INFANTS; CRITICAL ILLNESS; SERUM CORTISOL; BUDESONIDE; MORTALITY; THERAPY; SURFACTANT;

D O I：

10.1038/s41372-021-01251-y

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective To determine if extremely preterm (EPT) neonates receiving dexamethasone for the prevention of BPD have a higher incidence of presumed adrenal insufficiency (PAI). Study design Retrospective cohort study of neonates Result Of 332 neonates, 38% received dexamethasone. The incidence of PAI was higher in neonates who had received dexamethasone (20.8% vs 2.9%, p < 0.001). However, for intubated babies receiving surfactant, dexamethasone was not independently associated with increased PAI after adjusting for gestational age, birthweight, and race (aOR 2.92, 95% CI: 0.79-10.85). Dexamethasone was independently associated with increased PAI in infants previously receiving budesonide/surfactant treatment (aOR 5.38, 95% CI: 1.38-20.90). Conclusion The use of dexamethasone alone was not associated with increased PAI, when adjusted for prematurity-related factors. The combination of budesonide with dexamethasone was significantly associated with increased PAI.

引用

页码：65 / 71

页数：7

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