Role of TLR2-dependent inflammation in metastatic progression

被引：56

作者：

Kim, Sunhwa ^{[1
,2
,3
]}

Karin, Michael ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Ctr Canc, La Jolla, CA 92093 USA

[3] Johnson & Johnson Pharmaceut Res & Dev, San Diego, CA USA

来源：

YEAR IN IMMUNOLOGY | 2011年 / 1217卷

关键词：

Toll-like receptor; inflammation; TNF-alpha; tumor progression; metastasis; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; TOLL-LIKE RECEPTOR-4; MOBILITY GROUP BOX-1; HEAT-SHOCK PROTEINS; TGF-BETA; EPITHELIAL-CELLS; DENDRITIC CELLS; SIGNAL-TRANSDUCTION; IMMUNE-RESPONSE;

D O I：

10.1111/j.1749-6632.2010.05882.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammation is a part of the host defense system, which provides protection against invading pathogens. However, it has become increasingly clear that inflammation can be evoked by endogenous mediators through Toll-like receptors (TLRs) to enhance tumor progression and metastasis. Here, we discuss the roles of TLR-mediated inflammation in tumor progression and the mechanisms through which it accomplishes this pathogenic function.

引用

页码：191 / 206

页数：16

共 172 条

[1] Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant [J].

Adams, Sylvia ;

O'Neill, David W. ;

Nonaka, Daisuke ;

Hardin, Elizabeth ;

Chiriboga, Luis ;

Siu, Kimberly ;

Cruz, Crystal M. ;

Angiulli, Angelica ;

Angiulli, Francesca ;

Ritter, Erika ;

Holman, Rose Marie ;

Shapiro, Richard L. ;

Berman, Russell S. ;

Berner, Natalie ;

Shao, Yongzhao ;

Manches, Olivier ;

Pan, Linda ;

Venhaus, Ralph R. ;

Hoffman, Eric W. ;

Jungbluth, Achim ;

Gnjatic, Sacha ;

Old, Lloyd ;

Pavlick, Anna C. ;

Bhardwaj, Nina .

JOURNAL OF IMMUNOLOGY, 2008, 181 (01) :776-784

[2] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[3]

Akira S, 2007, CURR PROTOC IMMUNOL, DOI DOI 10.1002/0471142735.IM1412S77

[4]

Alberti C, 2008, EUR REV MED PHARMACO, V12, P167

[5] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[6] Interleukin 1-dependent and -independent mouse melanoma metastases [J].

Anasagasti, MJ ;

Olaso, E ;

Calvo, F ;

Mendoza, L ;

Martin, JJ ;

Bidaurrazaga, J ;

VidalVanaclocha, F .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (09) :645-651

[7] Interleukin-1 - a major pleiotropic cyrtokine in tumor-host interactions [J].

Apte, RN ;

Voronov, E .

SEMINARS IN CANCER BIOLOGY, 2002, 12 (04) :277-290

[8] Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway [J].

Arnott, CH ;

Scott, KA ;

Moore, RJ ;

Hewer, A ;

Phillips, DH ;

Parker, P ;

Balkwill, FR ;

Owens, DM .

ONCOGENE, 2002, 21 (31) :4728-4738

[9] Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development [J].

Arnott, CH ;

Scott, KA ;

Moore, RJ ;

Robinson, SC ;

Thompson, RG ;

Balkwill, FR .

ONCOGENE, 2004, 23 (10) :1902-1910

[10] Novel signal transduction pathway utilized by extracellular HSP70 -: Role of Toll-like receptor (TLR) 2 AND TLR4 [J].

Asea, A ;

Rehli, M ;

Kabingu, E ;

Boch, JA ;

Baré, O ;

Auron, PE ;

Stevenson, MA ;

Calderwood, SK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (17) :15028-15034

← 1 2 3 4 5 6 7 8 9 10 →