Chitosan sponges and polycaprolactone nanoparticles carrying tranexamic acid as hemostatic agent: Synthesis, characterization and bioapplication

被引：3

作者：

Fernandes dos Santos, Maria Carolina ^{[1
]}

dos Santos Cavalcante, Luiza Peixoto ^{[1
]}

de Andrade, Karlivania Ferreira ^{[1
]}

da Silva, Alan Frazao ^{[1
]}

Ferreira Muniz, Isis de Araujo ^{[2
]}

de Lima, Jefferson Muniz ^{[3
]}

Aguiar, Rebeca Tibau ^{[4
]}

Tavares, Josean Fechine ^{[5
]}

Cancado Castellano, Lucio Roberto ^{[1
]}

da Silva, Sabrina Daniela ^{[6
]}

Ferreti Bonan, Paulo Rogerio ^{[7
]}

机构：

[1] Univ Fed Paraiba, Hlth Sci Ctr, Tech Sch Hlth, Lab Cell Culture & Anal, Campus 1, Joao Pessoa, Paraiba, Brazil

[2] Univ Fed Paraiba, Hlth Sci Ctr, Post Grad Program Dent, Joao Pessoa, Paraiba, Brazil

[3] Univ Fed Pernambuco, Hlth Sci Ctr, Post Grad Program Dent, Recife, PE, Brazil

[4] Univ Fed Paraiba, Hlth Sci Ctr, Integrated Lab Biomat, Joao Pessoa, Paraiba, Brazil

[5] Univ Fed Paraiba, Lab Pharmaceut Technol, Joao Pessoa, Paraiba, Brazil

[6] McGill Univ, Dept Otolaryngol & Head & Neck Surg, Montreal, PQ, Canada

[7] Univ Fed Paraiba, Hlth Sci Ctr, Dept Clin & Social Dent, Joao Pessoa, Paraiba, Brazil

来源：

POLYMER ENGINEERING AND SCIENCE | 2022年 / 62卷 / 11期

关键词：

biocompatible materials; chitosan; hemostasis; tranexamic acid; ANTICOAGULATED PATIENTS; DENTAL EXTRACTION; ORAL-SURGERY; POLY(EPSILON-CAPROLACTONE); DELIVERY; BLEND; RISK;

D O I：

10.1002/pen.26139

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This study aimed to synthesize, characterize, and evaluate the hemagglutinating activity of chitosan sponges (Cs) and polycaprolactone nanoparticles transporting tranexamic acid. Sponges were prepared in various concentrations, lyophilized, and characterized by Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, scanning electron microscopy, zeta potential, profilometry, and nuclear magnetic resonance (H-1 NMR). Samples were evaluated for hemagglutinating potential and clotting time. The results confirmed the presence of the three components in the biomaterial, as well as stability in the oral environment since the loss of mass occurred only at high temperatures. Microscopy and profilometry demonstrated the samples' porosity. Hemagglutination was found to be complete in the Cs100PCL0, Cs75PCL25+TXA, Cs50PCL50+TXA, and Cs75PCL25 sponges, and those with chitosan in their composition presented reduced clotting times as compared to the control. The innovative Cs have stability, porosity, complete hemagglutination, and were able to significantly reduce clotting time.

引用

页码：3709 / 3720

页数：12

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