In vivo imaging of embryonic stem cell therapy

被引：14

作者：

Jiang, Han ^{[1
,2
,3
,4
,5
,6
]}

Cheng, Zhen ^{[5
,6
]}

Tian, Mei ^{[7
]}

Zhang, Hong ^{[1
,2
,3
,4
]}

机构：

[1] Zhejiang Univ, Dept Nucl Med, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Med PET Ctr, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 310009, Zhejiang, Peoples R China

[4] Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[5] Stanford Univ, MIPS, Dept Radiol, Bio X Program,Sch Med, Stanford, CA 94305 USA

[6] Stanford Univ, Stanford Canc Ctr, Sch Med, Stanford, CA 94305 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2011年 / 38卷 / 04期

基金：

美国国家科学基金会;

关键词：

Embryonic stem cells (ESCs); Imaging modality; Regenerative medicine; Therapy; POSITRON-EMISSION-TOMOGRAPHY; INSULIN-PRODUCING CELLS; ISCHEMIC RAT-BRAIN; MAGNETIC-RESONANCE; REPORTER GENE; QUANTUM DOTS; NEURODEGENERATIVE DISORDERS; OPTICAL BIOLUMINESCENCE; TRANSPLANTATION THERAPY; CARDIOVASCULAR-DISEASE;

D O I：

10.1007/s00259-010-1667-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Embryonic stem cells (ESCs) have the most pluripotent potential of any stem cell. These cells, isolated from the inner cell mass of the blastocyst, are "pluripotent," meaning that they can give rise to all cell types within the developing embryo. As a result, ESCs have been regarded as a leading candidate source for novel regenerative medicine therapies and have been used to derive diverse cell populations, including myocardial and endothelial cells. However, before they can be safely applied clinically, it is important to understand the in vivo behavior of ESCs and their derivatives. In vivo analysis of ESC-derived cells remains critically important to define how these cells may function in novel regenerative medicine therapies. In this review, we describe several available imaging modalities for assessing cell engraftment and discuss their strengths and limitations. We also analyze the applications of these modalities in assessing the utility of ESCs in regenerative medicine therapies.

引用

页码：774 / 784

页数：11

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