High prevalence of Autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: Concept of autoimmune exocrinopathy and endocrinopathy of the pancreas

被引:61
作者
Taniguchi, T
Okazaki, K
Okamoto, M
Seko, S
Tanaka, J
Uchida, K
Nagashima, K
Kurose, T
Yamada, Y
Chiba, T
Seino, Y
机构
[1] Ohtsu Red Cross Hosp, Dept Internal Med, Shiga, Japan
[2] Kansai Med Univ, Dept Internal Med 3, Osaka, Japan
[3] Kyoto Univ, Fac Med, Dept Endoscop Med & Gastroenterol, Kyoto, Japan
[4] Kyoto Univ, Fac Med, Dept Diabet & Clin Nutr, Kyoto, Japan
关键词
type; 1; diabetes; exocrine gland; autoantibody; autoimmune pancreatitis;
D O I
10.1097/00006676-200307000-00004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Introduction: Dysfunction of the exocrine as well as the endocrine pancreas has been reported in type 1 diabetes. Lymphocytic infiltration of the exocrine pancreas is observed in approximately half of Japanese type 1 diabetic patients. Aims: To investigate the involvement of autoimmunity against the exocrine pancreas in type 1 diabetes. Methodology: We examined autoantibodies against human carbonic anhydrase II (ACA) and lactoferrin (ALF), antigens in the pancreatic duct cells and the pancreatic acinus, respectively, in 43 type 1 diabetic patients and 20 type 2 diabetic patients using the enzyme-linked immunosorbent assay method. Results: Of 43 type 1 diabetic patients, ACA was detected in 28 patients (65%) and ALF was detected in 29 patients (67%). One or both of the antibodies were detected in 33 type 1 diabetic patients (77%). In contrast, neither ACA nor ALF were detected in type 2 diabetic patients. Conclusions: The high prevalence of both ACA and ALF strongly suggests the involvement of autoimmunity against the exocrine pancreas as well as the endocrine pancreas in some type 1 diabetic patients. We propose that these conditions be referred to as autoimmune exocrinopathy and endocrinopathy of the pancreas.
引用
收藏
页码:26 / 30
页数:5
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