Large-scale prospective genome-wide association study of oxaliplatin in stage II/III colon cancer and neuropathy

被引：6
|
作者：
Kanai, M. [1 ]
Kawaguchi, T. [2 ]
Kotaka, M. [3 ]
Manaka, D. [4 ]
Hasegawa, J. [5 ]
Takagane, A. [6 ]
Munemoto, Y. [7 ]
Kato, T. [8 ]
Eto, T. [9 ]
Touyama, T. [10 ]
Matsui, T. [11 ]
Shinozaki, K. [12 ]
Matsumoto, S. [13 ]
Mizushima, T. [14 ]
Mori, M. [15 ]
Sakamoto, J. [16 ,17 ]
Ohtsu, A. [18 ]
Yoshino, T. [18 ]
Saji, S. [16 ]
Matsuda, F. [2 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Therapeut Oncol, Kyoto, Japan
[2] Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan
[3] Sano Hosp, Gastrointestinal Canc Ctr, Kobe, Hyogo, Japan
[4] Kyoto Katsura Hosp, Gastrointestinal Ctr, Dept Surg, Kyoto, Japan
[5] Osaka Rosai Hosp, Dept Surg, Osaka, Japan
[6] Hakodate Goryoukaku Hosp, Dept Surg, Hakodate, Hokkaido, Japan
[7] Fukui Ken Saiseikai Hosp, Dept Surg, Fukui, Japan
[8] Kansai Rosai Hosp, Dept Surg, Amagasaki, Hyogo, Japan
[9] Tsuchiura Kyodo Gen Hosp, Dept Gastroenterol, Ibaraki, Japan
[10] Nakagami Hosp, Dept Surg, Okinawa City, Okinawa, Japan
[11] Aichi Hosp, Dept Gastroenterol Surg, Aichi Canc Ctr, Nagoya, Aichi, Japan
[12] Hiroshima Prefectural Hosp, Div Clin Oncol, Hiroshima, Japan
[13] Kyoto Univ, Grad Sch Med, Dept Real World Data Res & Dev, Kyoto, Japan
[14] Osaka Univ, Dept Gastroenterol Surg, Grad Sch Med, Osaka, Japan
[15] Kyushu Univ, Dept Surg & Sci, Fukuoka, Japan
[16] Japanese Fdn Multidisciplinary Treatment Canc, Tokyo, Japan
[17] Tokai Cent Hosp, Kakamigahara, Japan
[18] Natl Canc Ctr Hosp East, Dept Gastroenterol & Gastrointestinal Oncol, Chiba, Japan
来源：
ANNALS OF ONCOLOGY | 2021年 / 32卷 / 11期
关键词：
oxaliplatin; peripheral sensory neuropathy; genome-wide association study; pharmacogenomics; colon cancer; INDUCED PERIPHERAL NEUROPATHY; PHASE-III TRIAL; PHARMACOGENETIC PREDICTORS; ADJUVANT CHEMOTHERAPY; CUMULATIVE NEUROPATHY; POLYMORPHISMS; NEUROTOXICITY; ILE(105)VAL;
D O I：
10.1016/j.annonc.2021.08.1745
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The severity of oxaliplatin (L-OHP)-induced peripheral sensory neuropathy (PSN) exhibits substantial interpatient variability, and some patients suffer from long-term, persisting PSN. To identify single-nucleotide polymorphisms (SNPs) predicting L-OHP-induced PSN using a genome-wide association study (GWAS) approach. Patients and methods: A large prospective GWAS including 1379 patients with stage II/III colon cancer who received I.OHP-based adjuvant chemotherapy (mFOLFOX6/CAPDX) under the phase II (JOIN/JFMC41) or the phase III (ACHIVE/JFMC47) trial. Firstly, GWAS comparison of worst grade PSN (grade 0/1 versus 2/3) was carried out. Next, to minimize the impact of ambiguity in PSN grading, extreme PSN phenotypes were selected and analyzed by GWAS. SNPs that could predict time to recovery from PSN were also evaluated. In addition, SNPs associated with L-OHP-induced allergic reactions (AR) and time to disease recurrence were explored. Results: No SNPs exceeded the genome-wide significance (P < 5.0 x 10(-8)) in either GWAS comparison of worst grade PSN, extreme PSN phenotypes, or time to recovery from PSN. An association study focusing on AR or time to disease recurrence also failed to reveal any significant SNPs. Conclusion: Our results highlight the challenges of utilizing SNPs for predicting susceptibility to L-OHP-induced PSN in daily clinical practice.
引用
收藏
页码：1434 / 1441
页数：8
相关论文
共 50 条
  • [21] Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population
    Siew-Kee Low
    Yoon Ming Chin
    Hidemi Ito
    Keitaro Matsuo
    Chizu Tanikawa
    Koichi Matsuda
    Hiroko Saito
    Mika Sakurai-Yageta
    Naoki Nakaya
    Atsushi Shimizu
    Satoshi S. Nishizuka
    Taiki Yamaji
    Norie Sawada
    Motoki Iwasaki
    Shoichiro Tsugane
    Toshiro Takezaki
    Sadao Suzuki
    Mariko Naito
    Kenji Wakai
    Yoichiro Kamatani
    Yukihide Momozawa
    Yoshinori Murakami
    Johji Inazawa
    Yusuke Nakamura
    Michiaki Kubo
    Toyomasa Katagiri
    Yoshio Miki
    Scientific Reports, 9
  • [22] A Genome-Wide Association Study of Glaucomatous Optic Neuropathy
    Ramdas, W. D.
    van Koolwijk, L. M. E.
    Ikram, M. K.
    Lemij, H. G.
    Wolfs, R. C. W.
    de Jong, P. T. V. M.
    Jansonius, N. M.
    Vingerling, J. R.
    Klaver, C. C. W.
    van Duijn, C. M.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [23] Large-scale genome-wide association study identifiesHLAclass II variants associated with chronic HBV infection: a study from Taiwan Biobank
    Huang, Yu-Han
    Liao, Shu-Fen
    Khor, Seik-Soon
    Lin, Yu-Ju
    Chen, Hsuan-Yu
    Chang, Ya-Hsuan
    Huang, Yi-Hsiang
    Lu, Sheng-Nan
    Lee, Hye-Won
    Ko, Wen-Ya
    Huang, Claire
    Liu, Po-Chun
    Chen, Yen-Ju
    Wu, Ping-Feng
    Chu, Hou-Wei
    Wu, Pei-Ei
    Tokunaga, Katsushi
    Shen, Chen-Yang
    Lee, Mei-Hsuan
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 52 (04) : 682 - 691
  • [24] Large-Scale Genome-Wide Study of Income Highlights Heterogenous Pleiotropy Across the Genome
    Kweon, Hyeokmoon
    Burik, Casper A. P.
    Ahlskog, Rafael
    Okbay, Aysu
    Linner, Richard Karlsson
    de Vlaming, Ronald
    Benjamin, Daniel J.
    DiPrete, Thomas A.
    Koellinger, Philipp D.
    BEHAVIOR GENETICS, 2022, 52 (06) : 371 - 371
  • [25] Placental weight as a predictor of future health: Insights from a large-scale genome-wide association study
    Zhang, Qinyi
    Xu, Tianhan
    Yu, Sihui
    Wu, Sufang
    Yang, Ye
    Wu, Hao
    Zhang, Jiawen
    PLACENTA, 2025, 164 : 10 - 20
  • [26] Maliciously Secure and Efficient Large-Scale Genome-Wide Association Study With Multi-Party Computation
    Dong, Caiqin
    Weng, Jian
    Liu, Jia-Nan
    Yang, Anjia
    Liu, Zhiquan
    Yang, Yaxi
    Ma, Jianfeng
    IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING, 2023, 20 (02) : 1243 - 1257
  • [27] GENOME-WIDE ASSOCIATION STUDY OF DIABETIC NEUROPATHY IN UK BIOBANK
    Morsy, Heba
    Baskozos, Georgios
    Haddad, Saif
    Hoke, Ahmet
    Bennett, David
    Houlden, Henry
    Coleman, Michael
    Reilly, Mary
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2024, 29 : S60 - S61
  • [28] A Large-Scale Genome-Wide Association Study of Angiographically Determined Burden of Coronary Atherosclerosis in a Genetically Diverse Population
    Hilliard, Austin
    Zanetti, Daniela
    Lynch, Julie
    Damrauer, Scott M.
    Ho, Yuk-Lam
    Plomondon, Meg E.
    Waldo, Stephen
    Chang, Kyong-Mi
    Tsao, Philip S.
    Clarke, Shoa L.
    Assimes, Themistocles L.
    CIRCULATION, 2022, 146
  • [29] Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults
    Dahlin, Amber
    Sordillo, Joanne E.
    Ziniti, John
    Iribarren, Carlos
    Lu, Meng
    Weiss, Scott T.
    Tantisira, Kelan G.
    Lu, Quan
    Kan, Mengyuan
    Himes, Blanca E.
    Jorgenson, Eric
    Wu, Ann Chen
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (04) : 1633 - 1635
  • [30] Genome-wide association study of individual differences of human lymphocyte profiles using large-scale cytometry data
    Daigo Okada
    Naotoshi Nakamura
    Kazuya Setoh
    Takahisa Kawaguchi
    Koichiro Higasa
    Yasuharu Tabara
    Fumihiko Matsuda
    Ryo Yamada
    Journal of Human Genetics, 2021, 66 : 557 - 567
12345