Microchip-based synthesis and total analysis systems (μSYNTAS):: chemical microprocessing for generation and analysis of compound libraries

被引：63

作者：

Mitchell, MC ^{[1
]}

Spikmans, V ^{[1
]}

Manz, A ^{[1
]}

de Mello, AJ ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Zeneca SmithKline Beecham Ctr Analyt Sci, London SW7 2AY, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 05期

关键词：

D O I：

10.1039/b009037i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A miniaturised-SYNthesis and Total Analysis System (mu SYNTAS) integrating a silicon-machined chemical microprocessor and time-of-flight mass spectrometry (TOF-MS) is used for the generation of compound libraries based on sub-reactions of an Ugi multicomponent reaction (MCR). The microreactor-based on the concept of an AND logic operator-allowed the coupling of serially-switched solution-phase library generation with on-line compound analysis and identification. In addition, the mu SYNTAS allowed real-time parallel-processing of MCR sub-reactions; in contrast to combinatorial techniques employing a solid support for reagent and product isolation, the mu SYNTAS protocol required no additional preparation or work-up procedures.

引用

页码：514 / 518

页数：5

共 22 条

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