anticoagulant;
antithrombotic;
venous thromboembolism;
arterial thromboembolism;
direct thrombin inhibitor;
D O I:
10.1161/01.ATV.0000084827.77945.66
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The limitations of traditional anticoagulants, heparin and warfarin, have prompted the development of new anticoagulant drugs for prevention and treatment of both venous and arterial thromboembolism. After a brief review of thrombogenesis and its regulation, this study focuses on new anticoagulant agents in more advanced stages of clinical testing.
机构:
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy
Rossio, Raffaella
Mandelli, Sara
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机构:
Ist Ric Farmacol Mario Negri IRCCS, Lab Pharmacoepidemiol & Human Nutr, Dept Hlth Policy, Via Mario Negri 2, I-20156 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy
Mandelli, Sara
Ardoino, Ilaria
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机构:
Ist Ric Farmacol Mario Negri IRCCS, Lab Pharmacoepidemiol & Human Nutr, Dept Hlth Policy, Via Mario Negri 2, I-20156 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy
Ardoino, Ilaria
Nobili, Alessandro
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机构:
Ist Ric Farmacol Mario Negri IRCCS, Lab Pharmacoepidemiol & Human Nutr, Dept Hlth Policy, Via Mario Negri 2, I-20156 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy
Nobili, Alessandro
Peyvandi, Flora
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机构:
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy
Peyvandi, Flora
Mannucci, Pier Mannuccio
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机构:
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Angelo Bianchi Bon Hemophilia & Thrombosis Ctr, Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy
Mannucci, Pier Mannuccio
Franchi, Carlotta
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机构:
Ist Ric Farmacol Mario Negri IRCCS, Lab Pharmacoepidemiol & Human Nutr, Dept Hlth Policy, Via Mario Negri 2, I-20156 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy