Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial

被引：35

作者：

Venkatraman, Vijay K. ^{[1
,2
]}

Sanderson, Andrew ^{[1
,2
]}

Cox, Kay L. ^{[3
]}

Ellis, Kathryn A. ^{[4
]}

Steward, Christopher ^{[1
,2
]}

Phal, Pramit M. ^{[1
,2
]}

Gorelik, Alexandra ^{[1
,2
,5
]}

Sharman, Matthew J. ^{[6
]}

Villemagne, Victor L. ^{[7
,9
]}

Lai, Michelle ^{[4
,10
]}

Cyarto, Elizabeth, V ^{[10
]}

Merkel, Bernd ^{[1
,2
]}

Ames, David ^{[4
,10
]}

Szoeke, Cassandra ^{[1
,2
]}

Rowe, Christopher C. ^{[7
,8
]}

Masters, Colin L. ^{[9
]}

Lautenschlager, Nicola T. ^{[4
,11
]}

Desmond, Patricia M. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Dept Med & Radiol, Melbourne, Vic, Australia

[2] Royal Melbourne Hosp, Melbourne, Vic, Australia

[3] Univ Western Australia, Med Sch, Perth, WA, Australia

[4] Univ Melbourne, Acad Unit Psychiat Old Age, Dept Psychiat, Melbourne, Vic, Australia

[5] Royal Melbourne Hosp, Melbourne EpiCtr, Melbourne, Vic, Australia

[6] Univ Tasmania, Sch Hlth Sci, Launceston, Tas, Australia

[7] Austin Hlth, Dept Mol Imaging & Therapy, Melbourne, Vic, Australia

[8] Univ Melbourne, Melbourne Dementia Res Ctr, Melbourne, Vic, Australia

[9] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[10] Natl Ageing Res Inst, Melbourne, Vic, Australia

[11] Melbourne Hlth, NorthWestern Mental Hlth, Melbourne, Vic, Australia

来源：

NEUROBIOLOGY OF AGING | 2020年 / 89卷

基金：

英国医学研究理事会;

关键词：

White matter hyperintensity; Hippocampal loss; Physical activity; Intervention; Cognitive impairment; MILD COGNITIVE IMPAIRMENT; EXERCISE; INTERVENTION; DEMENTIA; VOLUME; SEGMENTATION; NEUROGENESIS; ASSOCIATION; HIPPOCAMPUS; PERFORMANCE;

D O I：

10.1016/j.neurobiolaging.2019.02.030

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：132 / 141

页数：10

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