Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

被引：442
作者：
Van Lint, Philippe
Libert, Claude
机构：
[1] Univ Ghent VIB, Dept Mol Biomed Res, Ghent, Belgium
[2] Univ Ghent VIB, Dept Mol Biol, Ghent, Belgium
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2007年 / 82卷 / 06期
关键词：
extracellular matrix; ELR; NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR-BETA; HERNIATED DISC RESORPTION; ACUTE LUNG INJURY; GELATINASE-B; AIRWAY INFLAMMATION; TGF-BETA; EXTRACELLULAR-MATRIX; CHEMOTACTIC ACTIVITY; MACROPHAGE ELASTASE;
D O I：
10.1189/jlb.0607338
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.
引用
收藏
页码：1375 / 1381
页数：7
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