Elastic properties of stored red blood cells from sickle trait donor units

被引：14
作者：
Brandao, MM
Saas, STO
Cezar, CL
Fontes, A
Costa, FF
Barjas-Castro, ML
机构：
[1] Univ Estadual Campinas, Hemoctr, BR-13083970 Campinas, SP, Brazil
[2] State Univ Campinas, Inst Fis Gleb Wataghin, Campinas, SP, Brazil
来源：
VOX SANGUINIS | 2003年 / 85卷 / 03期
关键词：
optical tweezers; RBC elasticity; sickle cell trait; storage;
D O I：
10.1046/j.1423-0410.2003.00344.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and Objectives Red blood cells (RBCs) from patients with sickle cell disease present reduced deformability. The aim of this study was to analyse the elasticity of stored RBCs from patients with the sickle cell trait ( AS). Materials and Methods The cell elasticity was studied, using laser optical tweezers, on storage days 1, 14, 21, 28 and 35. Results The elasticity of RBC from AS units stored for 1, 14 and 21 days was significantly greater compared with that of control RBC cells stored for the same time-period. More than 30% of the cells from AS units stored for 28 or 35 days were very rigid and escaped from the optical trap. Conclusions RBCs became rigid during storage, suggesting that haemoglobin S might compromise the cell elasticity.
引用
收藏
页码：213 / 215
页数：3
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