Recent developments of quinolone-based derivatives and their activities against Escherichia coli

被引：97

作者：

Gao, Feng ^{[1
]}

Wang, Peng ^{[1
]}

Yang, Hua ^{[2
]}

Miao, Qing ^{[2
]}

Ma, Long ^{[1
]}

Lu, Guangming ^{[1
]}

机构：

[1] Nanjing Univ, Dept Med Imaging, Jinling Hosp, Sch Med, Nanjing, Jiangsu, Peoples R China

[2] TRIUMF, Life Sci, Vancouver, BC, Canada

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 157卷

基金：

中国博士后科学基金;

关键词：

Quinolone derivatives; Hybrid compounds; Antibacterial; Escherichia coli; Structure-activity relationship; VITRO ANTIBACTERIAL ACTIVITY; MICROWAVE-ASSISTED SYNTHESIS; SELECTIVE SIDEROMYCIN ANTIBIOTICS; LINKED FLUOROQUINOLONE DIMERS; IN-VITRO; BIOLOGICAL EVALUATION; STAPHYLOCOCCUS-AUREUS; ACID-DERIVATIVES; METHICILLIN-RESISTANT; CIPROFLOXACIN DERIVATIVES;

D O I：

10.1016/j.ejmech.2018.08.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Escherichia coli (E. coli) is the most common pathogen in both hospital and community settings, and is capable of causing infections that can lead to serious consequences. Quinolones, one of the most common antibiotics in clinical use, are effective weapons to treat E. coil infections. However, the resistance of E. coli to quinolones develops rapidly and spreads widely. Thus, it has become increasingly urgent to enhance the potency of quinolones against both drug-susceptible and drug-resistant E. coli. This review aims to summarize the recent developments of quinolone derivatives with potential activity against E. coli, and to discuss the structure-activity relationship for further rationale design of this kind of derivatives. (C) 2018 Published by Elsevier Masson SAS.

引用

页码：1223 / 1248

页数：26

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