Cytoplasmic Intermediate Filaments in Cell Biology

被引:143
作者
Etienne-Manneville, Sandrine [1 ]
机构
[1] Inst Pasteur Paris, Equipe Labellisee Ligue Canc, Migrat & Canc Unit, Cell Polar,CNRS,UMR 3691, Paris 15, France
来源
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 | 2018年 / 34卷
关键词
cell mechanics; cell adhesion; keratin; vimentin; GFAP; nestin; neurofilaments; MICROTUBULE-DEPENDENT TRANSPORT; SIMPLE EPITHELIAL KERATINS; RHO-ASSOCIATED KINASE; VIMENTIN PHOSPHORYLATION; FOCAL ADHESION; CYCLE PROGRESSION; CANCER-CELLS; SHEAR-STRESS; VISCOELASTIC PROPERTIES; MECHANICAL-PROPERTIES;
D O I
10.1146/annurev-cellbio-100617-062534
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their stability, intrinsic mechanical properties, and cell type-specific expression patterns distinguish them from actin and microtubules. By providing mechanical support, IFs protect cells from external forces and participate in cell adhesion and tissue integrity. IFs form an extensive and elaborate network that connects the cell cortex to intracellular organelles. They act as a molecular scaffold that controls intracellular organization. However, IFs have been revealed as much more than just rigid structures. Their dynamics is regulated by multiple signaling cascades and appears to contribute to signaling events in response to cell stress and to dynamic cellular functions such as mitosis, apoptosis, and migration.
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页码:1 / 28
页数:28
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