Transforming growth factor-β, smads, and cancer

被引:18
作者
Grady, WM
机构
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA
[2] Seattle Canc Care Alliance, Seattle, WA USA
[3] Dept Vet Affairs Puget Sound Hlth Care Syst, Med Serv, Seattle, WA USA
[4] Univ Washington, Sch Med, Div Gastroenterol, Seattle, WA 98195 USA
关键词
D O I
10.1158/1078-0432.CCR-05-0414
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:3151 / 3154
页数:4
相关论文
共 31 条
[1]   T beta RI phosphorylation of Smad2 on Ser(465) and Ser(467) is required for Smad2-Smad4 complex formation and signaling [J].
Abdollah, S ;
MaciasSilva, M ;
Tsukazaki, T ;
Hayashi, H ;
Attisano, L ;
Wrana, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :27678-27685
[2]  
Attisano L., 2001, GENOME BIOL, V2, P8, DOI [10.1186/gb-2001-2-8-reviews3010, DOI 10.1186/GB-2001-2-8-REVIEWS3010]
[3]   Smad4 deffiency in cervical carcinoma cells [J].
Baldus, SE ;
Schwarz, E ;
Lohrey, C ;
Zapatka, M ;
Landsberg, S ;
Hahn, SA ;
Schmidt, D ;
Dienes, HP ;
Schmiegel, WH ;
Schwarte-Waldhoff, I .
ONCOGENE, 2005, 24 (05) :810-819
[4]   Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism [J].
Bhowmick, NA ;
Ghiassi, M ;
Bakin, A ;
Aakre, M ;
Lundquist, CA ;
Engel, ME ;
Arteaga, CL ;
Moses, HL .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (01) :27-36
[5]   Transforming growth factor β receptor type II inactivation promotes the establishment and progression of colon cancer [J].
Biswas, S ;
Chytil, A ;
Washington, K ;
Romero-Gallo, J ;
Gorska, AE ;
Wirth, PS ;
Gautam, S ;
Moses, HL ;
Grady, WM .
CANCER RESEARCH, 2004, 64 (14) :4687-4692
[6]   Determinants of specificity in TGF-β signal transduction [J].
Chen, YG ;
Hata, A ;
Lo, RS ;
Wotton, D ;
Shi, YG ;
Pavletich, N ;
Massagué, J .
GENES & DEVELOPMENT, 1998, 12 (14) :2144-2152
[7]   The transforming growth factor-β superfamily of receptors [J].
de Caestecker, M .
CYTOKINE & GROWTH FACTOR REVIEWS, 2004, 15 (01) :1-11
[8]   Role of transforming growth factor-β signaling in cancer [J].
de Caestecker, MP ;
Piek, E ;
Roberts, AB .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (17) :1388-1402
[9]   Characterization of functional domains within Smad4/DPC4 [J].
deCaestecker, MP ;
Hemmati, P ;
LarischBloch, S ;
Ajmera, R ;
Roberts, AB ;
Lechleider, RJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (21) :13690-13696
[10]   TGF-β signaling in tumor suppression and cancer progression [J].
Derynck, R ;
Akhurst, RJ ;
Balmain, A .
NATURE GENETICS, 2001, 29 (02) :117-129