Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women

被引：22

作者：

Llop, Sabrina ^{[1
,2
]}

Lopez-Espinosa, Maria-Jose ^{[1
,2
]}

Murcia, Mario ^{[1
,2
]}

Alvarez-Pedrerol, Mar ^{[2
,3
,4
]}

Vioque, Jesus ^{[2
,5
]}

Aguinagalde, Xabier ^{[6
]}

Julvez, Jordi ^{[2
,3
,4
]}

Aurrekoetxea, Juan J. ^{[7
,8
,9
]}

Espada, Mercedes ^{[10
]}

Santa-Marina, Loreto ^{[2
,7
,8
]}

Rebagliato, Marisa ^{[1
,2
,11
]}

Ballester, Ferran ^{[1
,2
]}

机构：

[1] Univ Jaume 1, Univ Valencia, FISABIO, Joint Res Unit Epidemiol & Environm Hlth, Valencia 46020, Spain

[2] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[3] Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain

[4] IMIM Hosp Mar, Municipal Inst Med Res, Barcelona 08003, Spain

[5] Univ Miguel Hernandez, Sant Joan dAlacant 03550, Spain

[6] Lab Salud Publ Alava, Vitoria 01002, Spain

[7] Subdirecc Salud Publ Gipuzkoa, Dept Sanidad Gobierno Vasco, San Sebastian 20013, Spain

[8] Biodonostia, Inst Invest Biomed, San Sebastian 20014, Spain

[9] Univ Basque Country UPV EHU, Dept Med Prevent & Salud Publ, San Sebastian 20014, Spain

[10] Dept Salud Gobierno Vasco, Lab Salud Publ Bizkaia, Derio 48160, Spain

[11] Univ Jaume 1, Castellon de La Plana 12071, Spain

来源：

ENVIRONMENTAL RESEARCH | 2015年 / 138卷

关键词：

Prenatal exposure; Endocrine disruption; Mercury; Thyroid; Iodine supplementation; CORD BLOOD; NEUROPSYCHOLOGICAL DEVELOPMENT; PSYCHOMOTOR DEVELOPMENT; INORGANIC MERCURY; PRENATAL EXPOSURE; CHILD-DEVELOPMENT; FISH CONSUMPTION; EXCESSIVE IODINE; LACTATING WOMEN; HEALTHY WOMEN;

D O I：

10.1016/j.envres.2015.02.026

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action between mercury and intake of iodine from different sources. Methods: The study population was 1407 pregnant women participating in the Spanish INMA birth cohort study. Total mercury concentrations were analyzed in cord blood. Thyroid hormones (THs) were measured in serum samples collected at 13.2 +/- 1.5 weeks of gestation. The association between mercury and TH levels was evaluated with multivariate linear regression models. Effect modification caused by iodine intake from supplements and diet was also evaluated. Results: The geometric means of TSH, TT3, FT4 and mercury were 1.1 mu U/L, 2.4 nmol/L, 10.5 pmol/L and 7.7 mu g/L, respectively. Mercury levels were marginally significantly associated with TT3 (beta: -0.05; 95%CI: -0.10, 0.01), but were neither associated with TSH nor FT4. The inverse association between mercury and TT3 levels was stronger among the iodine supplement consumers (-0.08; 95%Cl: -0.15, -0.02, interaction p-value=0.07). The association with FT4 followed the same pattern, albeit not significant. Conclusion: Prenatal mercury exposure was inversely associated with TT3 levels among women who took iodine supplements during pregnancy. These results could be of public health concern, although further research is needed. (C) 2015 Elsevier Inc. All rights

引用

页码：298 / 305

页数：8

共 49 条

[1] Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada) [J].