Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

被引:70
作者
Kocan, Beata [1 ,2 ]
Maziarz, Aleksandra [1 ,2 ]
Tabarkiewicz, Jacek [1 ,2 ]
Ochiya, Takahiro [3 ]
Banas-Zabczyk, Agnieszka [1 ,2 ]
机构
[1] Univ Rzeszow, Lab Stem Cells Biol, Dept Human Immunol, Chair Preclin Studies,Inst Expt & Clin Med,Fac Me, Ul Kopisto 2a, PL-35310 Rzeszow, Poland
[2] Univ Rzeszow, Ctr Innovat Res Med & Nat Sci, Fac Med, Ul Warzywna 1a, PL-35310 Rzeszow, Poland
[3] Natl Canc Ctr, Div Mol & Cellular Med, Tokyo 1040045, Japan
关键词
HUMAN BONE-MARROW; ISOLATED FAT-CELLS; PERFRINGENS ALPHA TOXIN; STROMAL CELLS; LIPOLYTIC HORMONES; DIFFERENTIATION; EXPANSION; GROWTH; METABOLISM; EXOSOMES;
D O I
10.1155/2017/1653254
中图分类号
Q813 [细胞工程];
学科分类号
摘要
There has been an increased interest in mesenchymal stem cells from adipose tissue, due to their abundance and accessibility with no ethical concerns. Their multipotent properties make them appropriate for regenerative clinical applications. It has been shown that adipose-derived stem cells (ASCs) may differ between the origin sites. Moreover, a variety of internal and external factors may affect their biological characteristics, as what we aimed to highlight in this review. It has been demonstrated that ASCs secrete multiple trophic factors that are capable of stimulating cell proliferation and differentiation and migration of various cell types. Particular attention should be given to exosomes, since it is known that they contribute to the paracrine effects of MSCs. Secretion of trophic agents by ASCs is thought to be in a greater importance for regenerative medicine applications, rather than cells engraftment to the site of injury and their differentiation ability. The surface marker profile of ASCs seems to be similar to that of the mesenchymal stem cells from bone marrow, although some molecular differences are observed. Thus, in this review, we have attempted to define trophic activity, as well as phenotypic characterization of ASCs, as crucial factors for therapeutic usage.
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页数:13
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