Regulatory T Cells in Hepatitis B and C Virus Infections

被引：58
作者：
Jung, Min Kyung [1 ]
Shin, Eui-Cheol [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Lab Immunol & Infect Dis, 291 Daehak Ro, Daejeon 34141, South Korea
来源：
IMMUNE NETWORK | 2016年 / 16卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Regulatory T cell; Hepatitis B virus; Hepatitis C virus; ANTIVIRAL IMMUNE-RESPONSE; IN-VITRO PROLIFERATION; GROWTH-FACTOR-BETA; VIRAL CLEARANCE; SELF-TOLERANCE; CUTTING EDGE; TGF-BETA; HCV; EXPANSION; MEMORY;
D O I：
10.4110/in.2016.16.6.330
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4(+)CD25(+)Foxp3(+) Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections.
引用
收藏
页码：330 / 336
页数：7
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