Food labeling issues for severe food allergic patients

被引:47
作者
Fiocchi, Alessandro [1 ]
Risso, Davide [2 ]
DunnGalvin, Audrey [3 ,4 ]
Gonzalez Diaz, Sandra N. [5 ,6 ]
Monaci, Linda [7 ,8 ]
Fierro, Vincenzo [1 ]
Ansotegui, Ignacio J. [9 ]
机构
[1] IRCCS, Allergy Unit, Bambino Gesu Childrens Hosp, Translat Res Pediat Special Area, Rome, Italy
[2] Soremartec Italia Srl, Ferrero Grp, Alba, CN, Italy
[3] Univ Coll Cork, Sch Appl Psychol, Cork, Ireland
[4] Sechenov Univ, Fac Paediat, Moscow, Russia
[5] Autonomous Univ Nuevo Leon, Fac Med, Monterrey, Nuevo Leon, Mexico
[6] Univ Hosp Dr Jose Eleuterio Gonzalez, Monterrey, Nuevo Leon, Mexico
[7] Natl Res Council Italy CNR, Inst Sci Food Prod ISPA, Via G Amendola 122-O, I-70126 Bari, Italy
[8] MoniQA Assoc, A-7540 Vienna, Austria
[9] Hosp Quironsalud Bizkaia, Dept Allergy & Immunol, Bilbao, Spain
关键词
Food labeling; Allergies; Allergens; VITAL; Analytical methods; UNITED-STATES; ANAPHYLAXIS; CHILDREN;
D O I
10.1016/j.waojou.2021.100598
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Food allergy carries high importance and responsibility, affecting an estimated 220 million people worldwide. It is a frequent cause of food-induced anaphylaxis, a life-threatening condition requiring a toll of about one death per 50 million people a year worldwide. In order to help patients to identify allergenic foods and thus avoid anaphylactic reactions, 66 countries over the 5 continents require by law that allergenic ingredients must be declared when used in prepackaged foods. Unfortunately, the mandatory allergen list is not uniform, but varies among different countries. The widespread adoption of Precautionary Allergen Labeling (PAL) results in a proliferation of unregulated PALs with different informative statements. In this situation, the need of a scientific consensus on the definition of food allergy and the identification of a tolerable risk with routinely used detection assays, considering not only the eliciting dose but also the food source, is urgent. The aim of this manuscript is: 1) to draw a picture of the global situation in terms of PALs, and 2) to highlight new approaches that could aid in tackling the problem of regulating the labeling of allergens. These include the Voluntary Incidental Trace Allergen Labelling (VITAL) system, which intersects reference doses and labelling decisions, and a direct quantification of trace amounts of allergens at lower limit of detection (LOD) levels in the food itself through proteomics. We here highlight how, although with some limitations, the steady advances in proteomic approaches possess higher sensitivity than the recommended VITAL reference doses, allowing the identification of allergens at much lower LOD levels than VITAL. Considering that each assay used to detect allergen in food products carries method-specific issues, a more comprehensive and harmonized approach implementing both quantitative and qualitative methods could help overcoming the risk stratification approach and the overuse of PALs, offering promise as the field moves forward towards improving consumers' quality of life.
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页数:8
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