Structural evaluation of the prefrontal cortex in schizophrenia

被引:212
|
作者
Buchanan, RW
Vladar, K
Barta, PE
Pearlson, GD
机构
[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21228 USA
[2] Johns Hopkins Sch Med, Dept Psychiat, Div Psychiat Neuroimaging, Baltimore, MD USA
来源
AMERICAN JOURNAL OF PSYCHIATRY | 1998年 / 155卷 / 08期
关键词
D O I
10.1176/ajp.155.8.1049
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Altered prefrontal cortical function has been repeatedly implicated in the pathophysiology of schizophrenia. Attempts to determine whether this altered function is associated with structural changes in the prefrontal cortex have been hampered by the failure to examine more anatomically and functionally homogeneous regions. The authors have developed a reliable set of anatomical landmarks for subdividing the prefrontal cortex into superior, middle, inferior, and orbital regions, in order to determine whether patients with schizophrenia exhibit selective morphological abnormalities of the prefrontal cortex. Method: Magnetic resonance imaging (MRI) studies were obtained in 24 normal control subjects (14 men and 10 women) and 18 patients with schizophrenia (12 men and six women) by using a high-resolution thin spoiled-gradient recall acquisition in the steady-state protocol. The MRI images were used to determine prefrontal gray matter volumes for the four prefrontal regions and prefrontal total gray and white volumes. Results: Patients with schizophrenia exhibited selective gray matter volume reductions in the right and left inferior prefrontal cortex. There were no significant group differences in the other prefrontal regions. Patients with schizophrenia also exhibited decreased prefrontal total white matter and total volumes; there was no significant difference in prefrontal total gray matter volume. Conclusions: Patients with schizophrenia are characterized by relatively selective reductions in inferior prefrontal cortex gray matter volumes.
引用
收藏
页码:1049 / 1055
页数:7
相关论文
共 50 条
  • [21] Medial prefrontal cortex, self, and schizophrenia
    Vinogradov, S
    Schulman, B
    Luks, T
    Simpson, G
    Glenn, S
    JOURNAL OF COGNITIVE NEUROSCIENCE, 2005, : 119 - 119
  • [22] PREFRONTAL CORTEX, MONOAMINES AND NEUROPSYCHOLOGICAL STUDIES IN SCHIZOPHRENIA
    STIP, E
    GODBOUT, R
    M S-MEDECINE SCIENCES, 1995, 11 (11): : 1531 - 1539
  • [23] Markers of inflammation in the prefrontal cortex of individuals with schizophrenia
    S G Fillman
    N Cloonan
    L C Miller
    C S Weickert
    Molecular Psychiatry, 2013, 18 : 133 - 133
  • [24] DORSOLATERAL PREFRONTAL CORTEX DYSFUNCTION IN DEPRESSION AND SCHIZOPHRENIA
    BENCH, CJ
    LIDDLE, PF
    FRISTON, KJ
    FRITH, CD
    GRASBY, PM
    FRACKOWIAK, RSJ
    DOLAN, RJ
    SCHIZOPHRENIA RESEARCH, 1994, 11 (02) : 151 - 151
  • [25] Increased extracellular clusterin in the prefrontal cortex in schizophrenia
    Athanas, Katina M.
    Mauney, Sarah L.
    Woo, Tsung-Ung W.
    SCHIZOPHRENIA RESEARCH, 2015, 169 (1-3) : 381 - 385
  • [26] Evidence for inhibitory deficits in the prefrontal cortex in schizophrenia
    Radhu, Natasha
    Dominguez, Luis Garcia
    Farzan, Faranak
    Richter, Margaret A.
    Semeralul, Mawahib O.
    Chen, Robert
    Fitzgerald, Paul B.
    Daskalakis, Zafiris J.
    BRAIN, 2015, 138 : 483 - 497
  • [27] Dendritic spine density in prefrontal cortex in schizophrenia
    Lynch, A
    Gentleman, SM
    Hirsch, SR
    Garey, LJ
    SCHIZOPHRENIA RESEARCH, 2000, 41 (01) : 105 - 105
  • [28] Oligodendroglial pathology in postmortem prefrontal cortex in schizophrenia
    Uranova, N
    Orlovskaya, D
    Vostrikov, V
    Rachmanova, V
    GLIA, 2003, : 27 - 27
  • [29] Lamination abnormalities in the prefrontal cortex of patients with schizophrenia
    Casanova, MF
    de Zeeuw, L
    Switala, A
    Kreczmanski, P
    Steinbusch, HWM
    Heinsen, H
    Schmitz, C
    BIOLOGICAL PSYCHIATRY, 2004, 55 : 214S - 215S
  • [30] Plasticity in the Prefrontal Cortex in Schizophrenia and Healthy Subjects
    Rajji, Tarek K.
    BIOLOGICAL PSYCHIATRY, 2013, 73 (09) : 246S - 246S