High regio- and stereoselective Barbier reaction of carbonyl compounds mediated by NaBF4/Zn (Sn) in water

被引：30

作者：

Zha, ZG ^{[1
]}

Xie, Z ^{[1
]}

Zhou, CL ^{[1
]}

Chang, MX ^{[1
]}

Wang, ZY ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2003年 / 27卷 / 09期

关键词：

D O I：

10.1039/b303187j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Studies with NaBF4/M (M = Zn or Sn) showed that this novel mediator facilitated allylation of a variety of carbonyl compounds in water and had a great influence on the diastereoselectivity of the addition. More importantly, alpha- and gamma-addition products of crotylations can be alternatively obtained under the control of this novel mediator. A reaction mechanism is proposed based on our quantum calculation and experimental results.

引用

页码：1297 / 1300

页数：4

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