Reaction of 4-methyl-2-trifluoromethyl-1,3-oxazin-6-one with indoles

被引：2

作者：

Usachev, Sergey A. ^{[1
]}

Tabatchikova, Kristina M. ^{[1
]}

Sevenard, Dmitri V. ^{[2
]}

Sosnovskikh, Vyacheslav Ya. ^{[1
]}

机构：

[1] Ural Fed Univ, Inst Nat Sci & Math, 51 Lenin Ave, Ekaterinburg 620000, Russia

[2] Hansa Fine Chem GmbH, Bremen Innovat & Technol Ctr, 1 Fahrenheitstr, D-28359 Bremen, Germany

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

indoles; 2-(indol-3-yl)-4-methyl-2-trifluoromethyl-2; 3-dihydro-1; 3-oxazin-6-ones; 1; 3-oxazin-6-one; pyrroles; nucleophilic addition; 1,3-OXAZIN-6-ONES; 4-ARYL-6-TRIFLUOROMETHYL-2-PYRONES; DERIVATIVES;

D O I：

10.1007/s10593-018-2359-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of indoles to 4-methyl-2-trifluoromethyl-1,3-oxazin-6-one in an acidic medium proceeds at the C-2 atom and leads to 2-(indol-3-yl)-4-methyl-2-trifluoromethyl-2,3-dihydro-1,3-oxazin-6-ones in 67-83% yields. Pyrroles and N,N-dimethylaniline either do not enter into a reaction of this type or form the addition products in very low yields (6-12%).

引用

页码：848 / 851

页数：4

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