New heterocycles from thienopyridocinnolines

被引：8

作者：

Badr, MZA ^{[1
]}

Geies, AA ^{[1
]}

Abbady, MS ^{[1
]}

Dahy, AA ^{[1
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1998年 / 76卷 / 04期

关键词：

thienopyridocinnolines; their pyrimido; triazolopyrimido; and heteroannelated systems;

D O I：

10.1139/cjc-76-4-469

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Cyano-4-(p-tolyl)pyrido [3,2-c]cinnolin-2( 1H) thione 3 was reacted with ct-halo ketones, eaters, or amides to give the intermediates, S-alkylated products 5b-h, respectively,which underwent intramolecular ring closure reactions with ethanolic sodium ethoxide to give thienopyridocinnolines 6a-h. Pyrimidothienopyridocinnolines 9 and 11 were obtained by treatment of oxazino compound 8 with hydrazine hydrate and ammonium acetate. Treatment of hydrazino derivative 13 with acetylacetone, triethylorthoformate carbon disulphide, ethyl chloroformate, and acetic anhydride afforded triazolopyrimidothienopyridocinnolines 14-16, 18, and 21, while with nitrous acid the corresponding tetrazolo compound 19 was produced.

引用

页码：469 / 476

页数：8

共 36 条

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