Synthesis of Inherently Chiral Calix[4]arenes: Stereocontrol through Ligand Choice

被引：43

作者：

Herbert, Simon A. ^{[1
]}

Arnott, Gareth E. ^{[1
]}

机构：

[1] Univ Stellenbosch, Dept Chem & Polymer Sci, ZA-7602 Matieland, South Africa

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 20期

关键词：

HEXAMETHYLPHOSPHORAMIDE HMPA; LITHIUM DIISOPROPYLAMIDE; LITHIATION; BUTYLLITHIUM; COMPLEXES; MECHANISM; BEHAVIOR; SOLVENT; DIMERS;

D O I：

10.1021/ol101909f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Employing a chiral oxazoline as an ortholithiation directing group allows the synthesis of inherently chiral calix[4]arenes suitable for elaboration into planar chiral molecules. An important finding has been that the diastereoselectivity of the reaction can be tuned by the choice of additive These results have bearing on the elucidation of the general mechanism of oxazoline-directed ortholithiation

引用

页码：4600 / 4603

页数：4

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