Fatal Sulfasalazine-Induced Eosinophilic Myocarditis in a Patient with Periodic Fever Syndrome

被引：12

作者：

Jeremic, Ivica ^{[1
,3
]}

Vujasinovic Stupar, Nada ^{[1
,3
]}

Terzic, Tatjana ^{[2
,3
]}

Damjanov, Nemanja ^{[1
,3
]}

Nikolic, Milos ^{[3
,4
]}

Bonaci-Nikolic, Branka ^{[3
,5
]}

机构：

[1] Univ Belgrade, Inst Rheumatol, Belgrade, Serbia

[2] Univ Belgrade, Inst Pathol, Belgrade, Serbia

[3] Univ Belgrade, Fac Med, Belgrade, Serbia

[4] Clin Ctr Serbia, Clin Dermatovenereol, Belgrade, Serbia

[5] Clin Ctr Serbia, Clin Allergy & Clin Immunol, Belgrade, Serbia

来源：

MEDICAL PRINCIPLES AND PRACTICE | 2015年 / 24卷 / 02期

关键词：

Eosinophilic myocarditis; Drug-induced hypersensitivity syndrome; Sulfasalazine; Hyper-IgD syndrome; Periodic fever syndrome; INDUCED HYPERSENSITIVITY SYNDROME;

D O I：

10.1159/000369584

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The aim of this paper is to report the first case of drug-induced eosinophilic myocarditis (EM) in a patient with hereditary periodic fever syndrome (PFS). Case: A 28-year-old man with hyper-IgD syndrome, one of the PFS, developed a sulfasalazine-induced systemic hypersensitivity reaction complicated by EM. Thirteen days after sulfasalazine introduction, which had been given for arthritis, the patient developed fever, facial/neck edema, rash and cardiogenic shock, and died within 8 h. The autopsy revealed hemophagocytosis, while acute heart failure caused by necrotizing EM was established as the cause of death. Conclusion: This was a case of drug-induced EM in a patient with PFS that had an atypical presentation, rapid evolution and poor outcome. (C) 2014 S. Karger AG, Basel

引用

页码：195 / 197

页数：3

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