A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer's Disease

被引:76
作者
Sun, Miao [1 ]
Ma, Kai [2 ]
Wen, Jie [3 ]
Wang, Guangxian [4 ]
Zhang, Changliang [4 ]
Li, Qi [3 ,5 ]
Bao, Xiaofeng [1 ,5 ]
Wang, Hui [1 ]
机构
[1] Nantong Univ, Sch Pharm, Dept Pharmacol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China
[2] Probiot Australia, Ormeau, Qld, Australia
[3] Beijing Allwegene Hlth, Beijing, Peoples R China
[4] Jiangsu Biodep Biotechnol, Jiangyin, Jiangsu, Peoples R China
[5] Nantong Univ, Key Lab Inflammat & Mol Drug Target Jiangsu Prov, Nantong, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; dementia; gut microbiome; neurodegenerative disorders; AMYLOID-BETA-PEPTIDE; ENTERIC NERVOUS-SYSTEM; HIPPOCAMPAL NEUROGENESIS; COGNITIVE IMPAIRMENT; INTESTINAL BARRIER; MOUSE MODEL; PROTEIN; CLEARANCE; MICROGLIA; RECEPTOR;
D O I
10.3233/JAD-190872
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alzheimer's disease (AD) is a neurodegenerative process characterized by loss of neurons in the hippocampus and cerebral cortex, leading to progressive cognitive decline. Pathologically, the hallmark of AD is accumulation of "senile" plaques composed of amyloid-beta (A beta) protein surrounding neurons in affected regions. Despite extensive research into AD pathogenesis and therapeutic targets, there remains no breakthroughs in its management. In recent years, there has been a spark of interest in the connection between the brain and gastrointestinal tract, referred to as the brain-gut axis, and its potential implications for both metabolic and neurologic disease. Moreover, the gastrointestinal flora, referred to as the microbiome, appears to exert significant influence over the brain-gut axis. With the need for expanded horizons in understanding and treating AD, many have turned to the brain-gut-microbiome axis for answers. Here we provide a review of the brain-gut-microbiome axis and discuss the evidence supporting alterations of the axis in the pathogenesis of AD. Specifically, we highlight the role for the microbiome in disruption of A beta metabolism/clearance, increased permeability of the blood-brain barrier and modulation of the neuroinflammatory response, and inhibition of hippocampal neurogenesis. The majority of the above described findings are the result of excellent, albeit basic and pre-clinical studies. Therefore, we conclude with a brief description of documented clinical support for brain-gut-microbiome axis alteration in AD, including potential microbiome-based therapeutics for AD. Collectively, these findings suggest that the brain-gut-microbiome axis may be a "lost link" in understanding and treating AD and call for future work.
引用
收藏
页码:849 / 865
页数:17
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