Combination of mineral trioxide aggregate and propolis promotes odontoblastic differentiation of human dental pulp stem cells through ERK signaling pathway

被引：19
|
作者：
Kim, Jae-Hwan [1 ]
Kim, Soo-Yung [1 ]
Woo, Su-Mi [2 ]
Jeong, Ha-Na [3 ]
Jung, Ji-Yeon [2 ]
Kim, Seon-Mi [1 ]
Lim, Hae-Soon [3 ,4 ]
机构：
[1] Chonnam Natl Univ, Dent Sci Res Inst, Sch Dent, Dept Pediat Dent, Yongbong Ro 33, Gwangju, South Korea
[2] Chonnam Natl Univ, Dent Sci Res Inst, Sch Dent, Dept Oral Physiol, Yongbong Ro 33, Gwangju, South Korea
[3] Chonnam Natl Univ, Dept Dent, Hwasun Hosp, Seoyang Ro 322, Hwasun Gun, Jeollanam Do, South Korea
[4] Chonnam Natl Univ, Dent Sci Res Inst, Sch Dent, Dept Dent Educ, Yongbong Ro 33, Gwangju 61186, South Korea
来源：
FOOD SCIENCE AND BIOTECHNOLOGY | 2019年 / 28卷 / 06期
关键词：
ERK signaling; Human dental pulp cells; Mineral trioxide aggregate; Odontoblastic differentiation; Propolis; MATRIX PROTEIN-1 DMP1; ODONTOGENIC DIFFERENTIATION; BIOLOGICAL-PROPERTIES; GENE-TRANSCRIPTION; TISSUES; BIOMINERALIZATION; PROLIFERATION; EXPRESSION;
D O I：
10.1007/s10068-019-00609-5
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The aim of this study is to investigate combined effects of mineral trioxide aggregate (MTA) and propolis on odontoblastic differentiation of human dental pulp stem cells (DPSCs) and to find a signaling pathway involved. Combination of MTA and propolis significantly up-regulated the expression of DSPP and DMP1, and facilitated a mineral nodule formation (p < 0.05). Treatments with MTA, propolis or combined increased the phosphorylation of extracellular signal-regulated kinases (ERK), one of mitogen-activated protein kinases signaling cascades during odontogenic differentiation of DPSCs (p < 0.05), and U0126, an inhibitor of ERK, decreased calcium deposits (p < 0.05). Combination of MTA and propolis promotes odontogenic differentiation and mineralization of DPSCs through ERK pathway.
引用
收藏
页码：1801 / 1809
页数：9
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