Iron-Sulfur Cluster Biosynthesis in Algae with Complex Plastids

被引:9
作者
Grosche, Christopher [1 ,2 ]
Diehl, Angelika [1 ,3 ]
Rensing, Stefan A. [2 ]
Maier, Uwe G. [1 ,3 ]
机构
[1] LOEWE Ctr Synthet Microbiol Synmikro, Marburg, Germany
[2] Philipps Univ Marburg, Plant Cell Biol, Marburg, Germany
[3] Philipps Univ Marburg, Cell Biol Lab, Marburg, Germany
来源
GENOME BIOLOGY AND EVOLUTION | 2018年 / 10卷 / 08期
关键词
iron-sulfur cluster; cytosolic iron-sulfur protein assembly (CIA); periplastidal compartment; Guillardia theta; Bigelowiella natans; Phaeodactylum tricornutum; DIATOM PHAEODACTYLUM-TRICORNUTUM; MITOCHONDRION-RELATED ORGANELLES; MINIMIZED EUKARYOTIC CYTOPLASM; NUCLEOMORPH GENOME SEQUENCE; PROTEIN BIOGENESIS; EVOLUTIONARY HISTORY; ARABIDOPSIS-THALIANA; BIGELOWIELLA-NATANS; DNA METABOLISM; IMAGE-ANALYSIS;
D O I
10.1093/gbe/evy156
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Plastids surrounded by four membranes harbor a special compartment between the outer and inner plastid membrane pair, the so-called periplastidal compartment (PPC). This cellular structure is usually presumed to be the reduced cytoplasm of a eukaryotic phototrophic endosymbiont, which was integrated into a host cell and streamlined into a plastid with a complex membrane structure. Up to date, no mitochondrion or mitochondrion-related organelle has been identified in the PPC of any representative. However, two prominent groups, the cryptophytes and the chlorarachniophytes, still harbor a reduced cell nucleus of symbiont origin, the nucleomorph, in their PPCs. Generally, many cytoplasmic and nucleus-located eukaryotic proteins need an iron-sulfur cofactor for their functionality. Beside some exceptions, their synthesis is depending on a so-called iron-sulfur complex (ISC) assembly machinery located in the mitochondrion. This machinery provides the cytoplasm with a still unknown sulfur component, which is then converted into iron-sulfur clusters via a cytosolic iron-sulfur protein assembly (CIA) machinery. Here, we investigated if a CIA machinery is present in mitochondrion-lacking PPCs. By using bioinformatic screens and in vivo-localizations of candidate proteins, we show that the presence of a PPC-specific CIA machinery correlates with the presence of a nucleomorph. Phylogenetic analyses of PPC- and host specific CIA components additionally indicate a complex evolution of the CIA machineries in organisms having plastids surrounded by four membranes.
引用
收藏
页码:2061 / 2071
页数:11
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