Infection with HIV-1 induces a decrease in mtDNA

被引:51
作者
Casula, M
Bosboom-Dobbelaer, I
Smolders, K
Otto, S
Bakker, M
de Baar, MP
Reiss, P
de Ronde, A
机构
[1] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Sanquin Res,Int Antiviral Therapy Evaluat Ctr, Amsterdam, Netherlands
[2] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Sanquin Res,Primagen, Amsterdam, Netherlands
[3] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Sanquin Res,Dept Clin Viroimmunol, Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
关键词
D O I
10.1086/429412
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cross-sectional studies have suggested that infection with human immunodeficiency virus (HIV) type 1 could reduce the mitochondrial DNA (mtDNA) content of blood cells. We investigated mtDNA content in peripheral blood mononuclear cells (PBMCs) obtained from 36 antiretroviral therapy naive documented HIV-1 seroconverters, before and after seroconversion. mtDNA content statistically significantly decreased 1 year after seroconversion and showed a nonsignificant decrease during the subsequent 4 years. These findings confirm that infection with HIV-1 may, itself, reduce mtDNA content, at least within PBMCs. This could have implications for the subsequent development of mitochondrial toxicities associated with the use of nucleoside analogue reverse-transcriptase inhibitors.
引用
收藏
页码:1468 / 1471
页数:4
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