Infection with HIV-1 induces a decrease in mtDNA

被引：51

作者：

Casula, M

Bosboom-Dobbelaer, I

Smolders, K

Otto, S

Bakker, M

de Baar, MP

Reiss, P

de Ronde, A

机构：

[1] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Sanquin Res,Int Antiviral Therapy Evaluat Ctr, Amsterdam, Netherlands

[2] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Sanquin Res,Primagen, Amsterdam, Netherlands

[3] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Sanquin Res,Dept Clin Viroimmunol, Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 191卷 / 09期

关键词：

D O I：

10.1086/429412

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cross-sectional studies have suggested that infection with human immunodeficiency virus (HIV) type 1 could reduce the mitochondrial DNA (mtDNA) content of blood cells. We investigated mtDNA content in peripheral blood mononuclear cells (PBMCs) obtained from 36 antiretroviral therapy naive documented HIV-1 seroconverters, before and after seroconversion. mtDNA content statistically significantly decreased 1 year after seroconversion and showed a nonsignificant decrease during the subsequent 4 years. These findings confirm that infection with HIV-1 may, itself, reduce mtDNA content, at least within PBMCs. This could have implications for the subsequent development of mitochondrial toxicities associated with the use of nucleoside analogue reverse-transcriptase inhibitors.

引用

页码：1468 / 1471

页数：4

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