A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia

被引：8

作者：

Paganin, Maddalena ^{[1
]}

Buldini, Barbara ^{[2
]}

Germano, Giuseppe ^{[3
]}

Seganfreddo, Elena ^{[2
]}

di Meglio, Annamaria ^{[3
]}

Magrin, Elisa ^{[2
]}

Grillo, Francesca ^{[2
]}

Pigazzi, Martina ^{[2
,3
]}

Rizzari, Carmelo ^{[4
]}

Cazzaniga, Giovanni ^{[4
]}

Khiabanian, Hossein ^{[5
,6
]}

Palomero, Teresa ^{[7
,8
]}

Rabadan, Raul ^{[5
,6
]}

Ferrando, Adolfo A. ^{[7
,8
,9
]}

Basso, Giuseppe ^{[2
]}

机构：

[1] Azienda Osped Padova, Clin Oncoematol Pediat, Padua, Italy

[2] Univ Padua, Dipartimento Salute Donna & Bambino, Padua, Italy

[3] Fdn Citta Speranza, Lab Oncoematol Pediat, Ist Ric Pediat, Fifth Floor,Corso Stati Uniti 4, I-35127 Padua, Italy

[4] Univ Milan, Ctr Ric Tettamanti, Clin Pediat, Milan, Italy

[5] Columbia Univ, Dept Syst Biol, New York, NY USA

[6] Columbia Univ, Dept Biomed Informat, New York, NY USA

[7] Columbia Univ, Inst Canc Genet, New York, NY USA

[8] Columbia Univ, Dept Pathol, New York, NY USA

[9] Columbia Univ, Dept Pediat, New York, NY 10027 USA

来源：

PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 09期

关键词：

switch lineage; T-ALL; whole-exome sequencing; ACTIVATING MUTATIONS; LINEAGE SWITCH; CHEMOTHERAPY; TRANSPLANT; AIEOP;

D O I：

10.1002/pbc.26054

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.

引用

页码：1660 / 1663

页数：4

共 18 条

[1] Different outcomes of allogeneic hematopoietic stem cell transplant in a pair of twins affected by juvenile myelomonocytic leukemia [J].

Cesaro, Simone ;

De Filippi, Paola ;

Di Meglio, Annamaria ;

Leszl, Anna ;

Donska, Svetlana ;

Zaccaron, Ada ;

Cagioni, Claudia ;

Galavotti, Roberta ;

Danesino, Cesare ;

Aprili, Fiorenza ;

Cugno, Chiara ;

te Kronnie, Geertruy ;

Zecca, Marco ;

Bresolin, Silvia .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2014, 99 (02) :208-212

[2] Childhood high-risk acute lymphoblastic leukemia in first remission: results after chemotherapy or transplant from the AIEOP ALL 2000 study [J].

Conter, Valentino ;

Valsecchi, Maria Grazia ;

Parasole, Rosanna ;

Putti, Maria Caterina ;

Locatelli, Franco ;

Barisone, Elena ;

Lo Nigro, Luca ;

Santoro, Nicola ;

Arico, Maurizio ;

Ziino, Ottavio ;

Pession, Andrea ;

Testi, Anna Maria ;

Micalizzi, Concetta ;

Casale, Fiorina ;

Zecca, Marco ;

Casazza, Gabriella ;

Tamaro, Paolo ;

La Barba, Gaetano ;

Notarangelo, Lucia Dora ;

Silvestri, Daniela ;

Colombini, Antonella ;

Rizzari, Carmelo ;

Biondi, Andrea ;

Masera, Giuseppe ;

Basso, Giuseppe .

BLOOD, 2014, 123 (10) :1470-1478

[3]

Della Starza I, 2015, BR J HAEMATOL

[4] Lineage Switching in Acute Leukemias: A Consequence of Stem Cell Plasticity? [J].

Dorantes-Acosta, Elisa ;

Pelayo, Rosana .

BONE MARROW RESEARCH, 2012,

[5]

Germano Giuseppe, 2006, Haematologica, V91, pECR09

[6] Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse [J].

Imataki, Osamu ;

Ohnishi, Hiroaki ;

Yamaoka, Genji ;

Arai, Takeshi ;

Kitanaka, Akira ;

Kubota, Yoshitsugu ;

Kushida, Yoshio ;

Ishida, Toshihiko ;

Tanaka, Terukazu .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2010, 15 (01) :112-115

[7] T-Cell acute lymphoblastic leukemia relapsing as acute myelogenous leukemia [J].

Mantadakis, Elpis ;

Danilatou, Vassiliki ;

Stiakaki, Eftichia ;

Paterakis, George ;

Papadhimitriou, Stefanos ;

Kalmanti, Maria .

PEDIATRIC BLOOD & CANCER, 2007, 48 (03) :354-357

[8] Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia [J].

Mullighan, Charles G. ;

Phillips, Letha A. ;

Su, Xiaoping ;

Ma, Jing ;

Miller, Christopher B. ;

Shurtleff, Sheila A. ;

Downing, James R. .

SCIENCE, 2008, 322 (5906) :1377-1380

[9] Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias [J].

Palomero, T. ;

McKenna, K. ;

O-Neil, J. ;

Galinsky, I. ;

Stone, R. ;

Suzukawa, K. ;

Stiakaki, E. ;

Kalmanti, M. ;

Fox, E. A. ;

Caligiuri, M. A. ;

Aster, J. C. ;

Look, A. T. ;

Ferrando, A. A. .

LEUKEMIA, 2006, 20 (11) :1963-1966

[10] Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia [J].

Pession, Andrea ;

Masetti, Riccardo ;

Rizzari, Carmelo ;

Putti, Maria Caterina ;

Casale, Fiorina ;

Fagioli, Franca ;

Luciani, Matteo ;

Lo Nigro, Luca ;

Menna, Giuseppe ;

Micalizzi, Concetta ;

Santoro, Nicola ;

Testi, Anna Maria ;

Zecca, Marco ;

Biondi, Andrea ;

Pigazzi, Martina ;

Rutella, Sergio ;

Rondelli, Roberto ;

Basso, Giuseppe ;

Locatelli, Franco .

BLOOD, 2013, 122 (02) :170-178

← 1 2 →