Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques

被引：55

作者：

Yan, Jin-wu ^{[1
]}

Zhu, Jia-ying ^{[1
]}

Zhou, Kai-xiang ^{[2
]}

Wang, Jin-sheng ^{[1
]}

Tan, Hui-ya ^{[1
]}

Xu, Zhong-yong ^{[1
]}

Chen, Shuo-bin ^{[3
]}

Lu, Yu-ting ^{[3
]}

Cui, Meng-chao ^{[2
]}

Zhang, Lei ^{[1
]}

机构：

[1] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Guangdong, Peoples R China

[2] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 71期

基金：

中国国家自然科学基金;

关键词：

ALZHEIMERS-DISEASE; PROBES; MITOCHONDRIA; IR-780;

D O I：

10.1039/c7cc05056a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-beta plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.

引用

页码：9910 / 9913

页数：4

共 35 条

[11] Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Jack, Clifford R., Jr.
Knopman, David S.
Jagust, William J.
Petersen, Ronald C.
Weiner, Michael W.
Aisen, Paul S.
Shaw, Leslie M.
Vemuri, Prashanthi
Wiste, Heather J.
Weigand, Stephen D.
Lesnick, Timothy G.
Pankratz, Vernon S.
Donohue, Michael C.
Trojanowski, John Q.
[J]. LANCET NEUROLOGY, 2013, 12 (02) : 207 - 216
[12] Killian O., 2015, CURR MED CHEM, V22, P3278
[13] Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal
Kim, Dokyoung
Moon, Hyunsoo
Baik, Sung Hoon
Singha, Subhankar
Jun, Yong Woong
Wang, Taejun
Kim, Ki Hean
Park, Byung Sun
Jung, Junyang
Mook-Jung, Inhee
Ahn, Kyo Han
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (21) : 6781 - 6789
[14] Hydrophobic IR-780 Dye Encapsulated in cRGD-Conjugated Solid Lipid Nanoparticles for NIR Imaging-Guided Photothermal Therapy
Kuang, Ye
Zhang, Kunchi
Cao, Yi
Chen, Xing
Wang, Kewei
Liu, Min
Pei, Renjun
[J]. ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (14) : 12217 - 12226
[15] Innovative diagnostic tools for early detection of Alzheimer's disease
Laske, Christoph
Sohrabi, Hamid R.
Frost, Shaun M.
Lopez-de-Ipina, Karmele
Garrard, Peter
Buscema, Massimo
Dauwels, Justin
Soekadar, Surjo R.
Mueller, Stephan
Linnemann, Christoph
Bridenbaugh, Stephanie A.
Kanagasingam, Yogesan
Martins, Ralph N.
O'Bryant, Sid E.
[J]. ALZHEIMERS & DEMENTIA, 2015, 11 (05) : 561 - 578
[16] A theranostic agent for in vivo near-infrared imaging of β-amyloid species and inhibition of β-amyloid aggregation
Li, Yinhui
Xu, Di
Ho, See-Lok
Li, Hung-Wing
Yang, Ronghua
Wong, Man Shing
[J]. BIOMATERIALS, 2016, 94 : 84 - 92
[17] Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes
Liu, Hongwu
Yang, Jian
Wang, Letian
Xu, Yungen
Zhang, Siyuan
Lv, Jie
Ran, Chongzhao
Li, Yuyan
[J]. FUTURE MEDICINAL CHEMISTRY, 2017, 9 (02) : 179 - 198
[18] A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells
Liu, Ying
Zhou, Jin
Wang, Linlin
Hu, Xiaoxiao
Liu, Xiangjun
Liu, Meirong
Cao, Zehui
Shangguan, Dihua
Tan, Weihong
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (38) : 12368 - 12374
[19] Indocyanine green fluorescence imaging in hepatobiliary surgery
Majlesara, Ali
Golriz, Mohammad
Hafezi, Mohammadreza
Saffari, Arash
Stenau, Esther
Maier-Hein, Lena
Mueller-Stich, Beat P.
Mehrabi, Arianeb
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2017, 17 : 208 - 215
[20] Clinical Amyloid Imaging
Mallik, Atul
Drzezga, Alex
Minoshima, Satoshi
[J]. SEMINARS IN NUCLEAR MEDICINE, 2017, 47 (01) : 31 - 43

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