Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques

被引：55

作者：

Yan, Jin-wu ^{[1
]}

Zhu, Jia-ying ^{[1
]}

Zhou, Kai-xiang ^{[2
]}

Wang, Jin-sheng ^{[1
]}

Tan, Hui-ya ^{[1
]}

Xu, Zhong-yong ^{[1
]}

Chen, Shuo-bin ^{[3
]}

Lu, Yu-ting ^{[3
]}

Cui, Meng-chao ^{[2
]}

Zhang, Lei ^{[1
]}

机构：

[1] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Guangdong, Peoples R China

[2] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 71期

基金：

中国国家自然科学基金;

关键词：

ALZHEIMERS-DISEASE; PROBES; MITOCHONDRIA; IR-780;

D O I：

10.1039/c7cc05056a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-beta plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.

引用

页码：9910 / 9913

页数：4

共 35 条

[1] Alzheimers Association, 2017, Alzheimers Dementia, V13, P325, DOI 10.1016/j.jalz.2017.02.001
[2] A Unique "Integration" Strategy for the Rational Design of Optically Tunable Near-Infrared Fluorophores
Chen, Hua
Dong, Baoli
Tang, Yonghe
Lin, Weiying
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 2017, 50 (06) : 1410 - 1422
[3] Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species
Chen, Xiaoqiang
Wang, Fang
Hyun, Ji Young
Wei, Tingwen
Qiang, Jian
Ren, Xintong
Shin, Injae
Yoon, Juyoung
[J]. CHEMICAL SOCIETY REVIEWS, 2016, 45 (10) : 2976 - 3016
[4] Clinical use of near-infrared fluorescence imaging with indocyanine green in thoracic surgery: a literature review
Chiu, Chien-Hung
Chao, Yin-Kai
Liu, Yun-Hen
Wen, Chih-Tsung
Chen, Wei-Hsun
Wu, Ching-Yang
Hsieh, Ming-Ju
Wu, Yi-Cheng
Liu, Hui-Ping
[J]. JOURNAL OF THORACIC DISEASE, 2016, 8 : S744 - S748
[5] Smart Near-Infrared Fluorescence Probes with Donor-Acceptor Structure for in Vivo Detection of β-Amyloid Deposits
Cui, Mengchao
Ono, Masahiro
Watanabe, Hiroyuki
Kimura, Hiroyuki
Liu, Boli
Saji, Hideo
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (09) : 3388 - 3394
[6] Recent progress in the development of near-infrared fluorescent probes for bioimaging applications
Guo, Zhiqian
Park, Sookil
Yoon, Juyoung
Shin, Injae
[J]. CHEMICAL SOCIETY REVIEWS, 2014, 43 (01) : 16 - 29
[7] Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor
Hatai, Joydev
Motiei, Leila
Margulies, David
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (06) : 2136 - 2139
[8] Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms
He, Longwei
Dong, Baoli
Liu, Yong
Lin, Weiying
[J]. CHEMICAL SOCIETY REVIEWS, 2016, 45 (23) : 6449 - 6461
[9] Alzheimer's Disease in Primary Care: The Significance of Early Detection, Diagnosis, and Intervention
Herman, Lawrence
Atri, Alireza
Salloway, Stephen
[J]. AMERICAN JOURNAL OF MEDICINE, 2017, 130 (06) : 756 - 756
[10] Near-infrared fluorophores for biomedical imaging
Hong, Guosong
Antaris, Alexander L.
Dai, Hongjie
[J]. NATURE BIOMEDICAL ENGINEERING, 2017, 1 (01):

← 1 2 3 4 →