Cell polarity control by Wnt morphogens

被引：5
作者：
Chen, Chung-Kuan [1 ,2 ]
Pan, Chun-Liang [1 ,3 ]
机构：
[1] Natl Taiwan Univ, Inst Mol Med, Coll Med, Taipei, Taiwan
[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Program Biomed Sci, Tsukuba, Japan
[3] Natl Taiwan Univ, Inst Mol Med, Coll Med, Chung Shan South Rd, Taipei 10002, Taiwan
来源：
DEVELOPMENTAL BIOLOGY | 2022年 / 487卷
关键词：
HOX GENE-EXPRESSION; NEUROBLAST MIGRATION; C; ELEGANS; SIGNALING PATHWAYS; NEURONAL POLARITY; AXON GUIDANCE; DIVISION; PROTEIN; ORIENT; OUTGROWTH;
D O I：
10.1016/j.ydbio.2022.04.007
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cell polarity is regulated by both intrinsic properties of the cell and extrinsic factors in the environment. Wnts are secreted glycoproteins in graded distribution, and they function as morphogens to instruct cell fate and as guidance cues to steer axon growth cone, respectively. Recent studies suggest that Wnts also instruct cell polarization in diverse contexts, by engaging cytoskeletal machineries or transcriptional mechanisms. Here we review the literature of cell polarity control by Wnt glycoproteins, with an emphasis on the nematode Caenorhabditis elegans, a multi-cellular organism in which the importance of polarity-inducing factors can be verified in vivo. In both embryonic and postembryonic cell lineages that undergo asymmetric division, Wnts act as directional signals to instruct the asymmetry of mitosis. In C. elegans, Wnts polarize neuroblasts to control their directional migration, and they also specify axon-dendrite polarity by providing spatial instruction for postmitotic neurons. Together this review summarizes recent advances and unsolved issues in cell polarity control by Wnt glycoproteins.
引用
收藏
页码：34 / 41
页数：8
相关论文
共 57 条
[1]   Morphogen rules: design principles of gradient-mediated embryo patterning [J].
Briscoe, James ;
Small, Stephen .
DEVELOPMENT, 2015, 142 (23) :3996-4009
[2]   ORGANIZATION OF NEURONAL MICROTUBULES IN THE NEMATODE CAENORHABDITIS-ELEGANS [J].
CHALFIE, M ;
THOMSON, JN .
JOURNAL OF CELL BIOLOGY, 1979, 82 (01) :278-289
[3]   Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution [J].
Chen, Bi-Chang ;
Legant, Wesley R. ;
Wang, Kai ;
Shao, Lin ;
Milkie, Daniel E. ;
Davidson, Michael W. ;
Janetopoulos, Chris ;
Wu, Xufeng S. ;
Hammer, John A., III ;
Liu, Zhe ;
English, Brian P. ;
Mimori-Kiyosue, Yuko ;
Romero, Daniel P. ;
Ritter, Alex T. ;
Lippincott-Schwartz, Jennifer ;
Fritz-Laylin, Lillian ;
Mullins, R. Dyche ;
Mitchell, Diana M. ;
Bembenek, Joshua N. ;
Reymann, Anne-Cecile ;
Boehme, Ralph ;
Grill, Stephan W. ;
Wang, Jennifer T. ;
Seydoux, Geraldine ;
Tulu, U. Serdar ;
Kiehart, Daniel P. ;
Betzig, Eric .
SCIENCE, 2014, 346 (6208) :439-+
[4]  
Chen C.-K., 2014, THESIS NATL TAIWAN U
[5]   Early Events in Axon/Dendrite Polarization [J].
Cheng, Pei-lin ;
Poo, Mu-ming .
ANNUAL REVIEW OF NEUROSCIENCE, VOL 35, 2012, 35 :181-201
[6]   Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1 [J].
Chien, Shih-Chieh Jason ;
Gurling, Mark ;
Kim, Changsung ;
Craft, Teresa ;
Forrester, Wayne ;
Garriga, Gian .
DEVELOPMENTAL BIOLOGY, 2015, 404 (01) :55-65
[7]   Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway [J].
de Groot, Reinoud E. A. ;
Ganji, Ranjani S. ;
Bernatik, Ondrej ;
Lloyd-Lewis, Bethan ;
Seipel, Katja ;
Sedova, Katerina ;
Zdrahal, Zbynek ;
Dhople, Vishnu M. ;
Dale, Trevor C. ;
Korswagen, Hendrik C. ;
Bryja, Vitezslav .
SCIENCE SIGNALING, 2014, 7 (317)
[8]  
DOTTI CG, 1988, J NEUROSCI, V8, P1454
[9]   Visual Map Development: Bidirectional Signaling, Bifunctional Guidance Molecules, and Competition [J].
Feldheim, David A. ;
O'Leary, Dennis D. M. .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (11) :a001768
[10]   Wnt signals can function as positional cues in establishing cell polarity [J].
Goldstein, B ;
Takeshita, H ;
Mizumoto, K ;
Sawa, H .
DEVELOPMENTAL CELL, 2006, 10 (03) :391-396
123456