Methylation Status of the Serotonin Transporter Promoter CpG Island Is Associated With Major Depressive Disorder in Chinese Han Population A Case-Control Study

被引:8
作者
Shi, Mei [1 ]
Sun, Hongli [2 ]
Xu, Ye [1 ]
Wang, Zhenhua [3 ]
Cui, Hongyu [1 ]
Wang, Chengmin [1 ]
Liu, Wei [1 ]
An, Ganghui [1 ]
Hu, Jian [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat & Psychol, 23 Youzheng St, Harbin 150001, Heilongjiang, Peoples R China
[2] Weifang Mental Hlth Ctr, Dept Psychiat & Psychol, Harbin, Heilongjiang, Peoples R China
[3] Third Peoples Hosp Huzhou, Dept Psychiat & Psychol, Huzhou, Zhejiang, Peoples R China
关键词
Serotonin transporter; major depressive disorder; DNA methylation; Hamilton Rating Scale for Depression; RISK-FACTOR; EPIGENETIC REGULATION; GENE POLYMORPHISMS; ALCOHOL; METAANALYSIS; EXPRESSION; GENOTYPE; LIFE;
D O I
10.1097/NMD.0000000000000600
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This study was aimed to investigate the relationship between the methylation status of serotonin transporter (5-HTT) and major depressive disorder (MDD) in Chinese Han population. A total of 96 patients with MDD and 55 healthy volunteers were recruited, and the methylation index (MtI) at six positions in the cytosine-phosphate-guanosine island of 5-HTT gene was measured for each subject using bisulfite pyrosequencing. MtIs at positions 5 and 6 were higher in patients with MDD than those in controls. According to the multivariable logistic regression analysis, MtIs at positions 4 and 5 were significantly associated with MDD. Besides, depression education was an independent risk factor, whereas higher educational levels were protective factors for MDD. In addition, positions 1 and 4 were negatively correlated with weight and diurnal variation. Therefore, 5-HTT methylation might be closely related with MDD in Chinese Han population because of the correlation with diurnal variation and weight.
引用
收藏
页码:641 / 646
页数:6
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