Radiotherapy dose painting by circadian rhythm based radiomics

Radiotherapy dose painting is a new dose delivery technique to achieve higher treatment outcome. In this approach, does is escalated to high progressive regions which are heterogeneous and determined by advanced medical imaging. Radiomics is issued as a feasible image quantification method to reveal tumor heterogeneity by extraction of high throughput mineable texture features. On the other hand, circadian rhythm is a given biological process that studied as a critical factor to obtain more effective treatment outcome. In this study, we hypothesized that radiotherapy dose painting could be enhanced by using circadian rhythm that is determined on the radiomics maps obtained from medical images. This hypothesis is based on the idea which circadian rhythm could change the tumor heterogeneity and therefore image features.