Molecular characterization of the iron-hydroxamate uptake system in Staphylococcus aureus

被引：30

作者：

Cabrera, G ^{[1
]}

Xiong, AM ^{[1
]}

Uebel, M ^{[1
]}

Singh, VK ^{[1
]}

Jayaswal, RK ^{[1
]}

机构：

[1] Illinois State Univ, Dept Sci Biol, Microbiol Grp, Normal, IL 61790 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2001年 / 67卷 / 02期

关键词：

D O I：

10.1128/AEM.67.2.1001-1003.2001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To investigate iron uptake, a chromosomal locus containing three consecutive open reading frames, designated fhuC, fhuB, and fhuD, was identified in Staphylococcus aureus. Whereas the fhuC gene encodes an ATP-binding protein, fhuB and fhuD code for ferrichrome permeases and thus resemble an ATP-binding cassette transporter. A fhuB knockout mutant showed impaired uptake of iron bound to the siderophores but not of ferric chloride, suggesting that this operon is specific for siderophore-mediated iron uptake.

引用

页码：1001 / 1003

页数：3

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