Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

被引:19
|
作者
Heidrich, Vitor [1 ,2 ]
Bruno, Julia S. [1 ]
Knebel, Franciele H. [1 ]
de Molla, Vinicius C. [3 ,4 ]
Miranda-Silva, Wanessa [1 ]
Asprino, Paula F. [1 ]
Tucunduva, Luciana [3 ]
Rocha, Vanderson [3 ,5 ,6 ]
Novis, Yana [3 ]
Arrais-Rodrigues, Celso [3 ,4 ]
Fregnani, Eduardo R. [3 ]
Camargo, Anamaria A. [1 ]
机构
[1] Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil
[3] Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
[4] Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
[5] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Canc Estado Sao Paulo ICESP, Sao Paulo, Brazil
[6] Churchill Hosp, Natl Hlth Serv Blood & Transplant, Oxford, England
来源
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金
巴西圣保罗研究基金会;
关键词
oral microbiota; supragingival plaque; microbiome dysbiosis; acute GVHD; allogeneic HSCT; bone marrow transplant; GUT MICROBIOME; ORAL MICROBIOME; COLONIZATION; INHIBITION; DIVERSITY; PATHOGENS; DIAGNOSIS; BACTERIA; PROJECT; GVHD;
D O I
10.3389/fimmu.2021.692225
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity and changes in DBM genera composition, with commensal genera reductions and potentially pathogenic bacteria overgrowths. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with a higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom during allo-HSCT was observed in 17% of allo-HSCT recipients and was associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT.
引用
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页数:11
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