A convenient method for the alkylation of sulfamides using alkyl bromides and Mitsunobu betaine

被引：10

作者：

Winum, JY ^{[1
]}

Barragan, V ^{[1
]}

Montero, JL ^{[1
]}

机构：

[1] Univ Montpellier 2, UMR 5032, Lab Chim Biomol, F-34095 Montpellier 05, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 04期

关键词：

sulfamides; Mitsunobu betaine; glycosylation; alkyl bromide;

D O I：

10.1016/S0040-4039(00)02012-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alkylation of N-Boc-N'-(2-chloroethyl)sulfamide 1 by electron-deficient alkyl bromides using the Mitsunobu reagent as mild base is described. This method was also applied to the N-glycosylation of various carbohydrates and was anomerically selective. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：601 / 603

页数：3

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