Sugar-dependent photocytotoxic property of tetra- and octa-glycoconjugated tetraphenylporphyrins

被引：53

作者：

Mikata, Y ^{[1
]}

Onchi, Y ^{[1
]}

Tabata, K ^{[1
]}

Ogura, S ^{[1
]}

Okura, I ^{[1
]}

Ono, H ^{[1
]}

Yano, S ^{[1
]}

机构：

[1] Nara Womens Univ, Fac Sci, Dept Chem, Nara 6308506, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 25期

关键词：

photodynamic therapy; porphyrin and analogues; glycosides; oxygen; singlet;

D O I：

10.1016/S0040-4039(98)00801-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New tetraphenylporphyrin derivatives having eight glucose molecules were synthesized. Phototoxicity of these compounds against the HeLa cell line were compared to tetraglycosylated tetraphenylporphyrins. The highest activity was observed for a derivative having four OH-protected glucose moieties. Singlet oxygen producing ability was also examined to explain the difference in photocytotoxicities. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4505 / 4508

页数：4

共 19 条

[1] PHOTOSENSITIZERS OF THE PORPHYRIN AND PHTHALOCYANINE SERIES FOR PHOTODYNAMIC THERAPY [J].