Epstein-Barr virus in patients with persistent lymphadenopathy

被引：0

作者：

Melikyan, A. L. ^{[1
]}

Garanzha, T. A. ^{[1
]}

Tikhomirov, D. S. ^{[1
]}

Kaplanskaya, I. B. ^{[1
]}

Varlamova, E. Yu ^{[1
]}

Kovalyova, L. G. ^{[1
]}

Filatov, F. P. ^{[1
]}

机构：

[1] Hematol Res Ctr, Moscow, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2007年 / 52卷 / 04期

关键词：

stubborn lymphadenopathy; Epstein-Barr virus; serological diagnosis; immunohistochemistry;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A retrospective analysis of clinical laboratory findings in 62 patients with persistent relapsing lymphadenopathy of obscure etiology was carried out. Virus-specific markers of active infection (IgM-VCA, IgG-EA) or a previous infection caused by Epstein-Barr virus (EBV) (EgG-EBNA-1) were detected in the serum of 57 patients. Positive staining of histological preparations of biopsy specimens of the lymph nodes by EBV-specific antibodies to EBNA-2 indicated the fact of EBV infection but did not characterize the infection phase. A criteria for evaluating the activity of EBV infection during other than the active period is suggested. An inverse relationship between the level of beta-globulins and level of IgG-EBNA-1 antibodies was detected, which can serve as a marker of immunodeficiency in EBV infection.

引用

收藏

页码：21 / 27

页数：7

相关论文

共 26 条

[1] EBV persistence in memory B cells in vivo [J].

Babcock, GJ ;

Decker, LL ;

Volk, M ;

Thorley-Lawson, DA .

IMMUNITY, 1998, 9 (03) :395-404

[2] FREQUENCY OF CHRONIC ACTIVE EPSTEIN-BARR VIRUS-INFECTION IN A GENERAL MEDICAL-PRACTICE [J].

BUCHWALD, D ;

SULLIVAN, JL ;

KOMAROFF, AL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (17) :2303-2307

[3] The role of complement and complement receptors in induction and regulation of immunity [J].

Carroll, MC .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :545-568

[4] CHRONIC MONONUCLEOSIS SYNDROME [J].

DUBOIS, RE ;

SEELEY, JK ;

BRUS, I ;

SAKAMOTO, K ;

BALLOW, M ;

HARADA, S ;

BECHTOLD, TA ;

PEARSON, G ;

PURTILO, DT .

SOUTHERN MEDICAL JOURNAL, 1984, 77 (11) :1376-1382

[5] VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITTS LYMPHOMA [J].

EPSTEIN, MA ;

ACHONG, BG ;

BARR, YM .

LANCET, 1964, 1 (733) :702-+

[6] GAMMA-INTERFERON FOR SEVERE CHRONIC ACTIVE EPSTEIN-BARR-VIRUS [J].

FUJISAKI, T ;

NAGAFUCHI, S ;

OKAMURA, T .

ANNALS OF INTERNAL MEDICINE, 1993, 118 (06) :474-475

[7] ERADICATION OF EPSTEIN-BARR VIRUS BY ALLOGENEIC BONE-MARROW TRANSPLANTATION - IMPLICATIONS FOR SITES OF VIRAL LATENCY [J].

GRATAMA, JW ;

OOSTERVEER, MAP ;

ZWAAN, FE ;

LEPOUTRE, J ;

KLEIN, G ;

ERNBERG, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) :8693-8696

[8] Comparison of intravenous ganciclovir followed by oral acyclovir with intravenous ganciclovir alone for prevention of cytomegalovirus and Epstein-Barr virus disease after liver transplantation in children [J].

Green, M ;

Kaufmann, M ;

Wilson, J ;

Reyes, J .

CLINICAL INFECTIOUS DISEASES, 1997, 25 (06) :1344-1349

[9]

Johansen LV, 1997, CLIN OTOLARYNGOL, V22, P123

[10] T-CELL LYMPHOMAS CONTAINING EPSTEIN-BARR VIRAL-DNA IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS-INFECTIONS [J].

JONES, JF ;

SHURIN, S ;

ABRAMOWSKY, C ;

TUBBS, RR ;

SCIOTTO, CG ;

WAHL, R ;

SANDS, J ;

GOTTMAN, D ;

KATZ, BZ ;

SKLAR, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (12) :733-741