The benefits of a patient-specific head support, developed to improve immobilization during radiotherapy, were determined in head-and-neck cancer patients. Cone-beam CTs were registered to the planning CT in five regions. Compared to the standard head support, the individual head support decreased the systematic and random error of the inter- and intrafraction displacements and reduced deformations. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 96 (2010) 100-103