Extracts of Magnolia Species-Induced Prevention of Diabetic Complications: A Brief Review

被引：21
作者：
Zhao, Xuezhong [1 ]
Li, Fengsheng [2 ,3 ]
Sun, Wanqing [4 ,5 ]
Gao, Ling [6 ]
Kim, Ki Soo [7 ]
Kim, Kyoung Tae [7 ]
Cai, Lu [2 ]
Zhang, Zhiguo [1 ,2 ]
Zheng, Yang [1 ]
机构：
[1] Jilin Univ, Dept Cardiol, Hosp 1, Changchun 130021, Peoples R China
[2] Univ Louisville, Kosair Children Hosp Res Inst, Dept Pediat, Louisville, KY 40202 USA
[3] PLA Rocket Force, Gen Hosp, Beijing 100088, Peoples R China
[4] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis China, Beijing 100037, Peoples R China
[5] Peking Union Med Coll, Beijing 100037, Peoples R China
[6] China Ctr Dis Control, Natl Inst Radiol Protect, Key Lab Radiol Protect & Nucl Emergency, Beijing 100088, Peoples R China
[7] Bioland Biotec Co Ltd, Zhangjiang Modern Med Device Pk, Shanghai 201203, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Magnolia; diabetic complications; oxidative stress; INSULIN-RESISTANCE; GLUCOSE-UPTAKE; LIPID-ACCUMULATION; OXIDATIVE STRESS; LIVER-DISEASE; HONOKIOL; RISK; CARDIOMYOPATHY; INFLAMMATION; PATHOGENESIS;
D O I：
10.3390/ijms17101629
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetic complications are the major cause of mortality for the patients with diabetes. Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases. Several studies have established the anti-inflammatory and oxidative roles of bioactive constituents in Magnolia bark, which has been widely used in the traditional herbal medicines in Chinese society. These findings have attracted various scientists to investigate the effect of bioactive constituents in Magnolia bark on diabetic complications. The aim of this review is to present a systematic overview of bioactive constituents in Magnolia bark that induce the prevention of obesity, hyperglycemia, hyperlipidemia, and diabetic complications, including cardiovascular, liver, and kidney.
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页数：11
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