Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system

被引：85

作者：

Gerbe, F. ^{[1
,2
,3
]}

Jay, P. ^{[1
,2
,3
]}

机构：

[1] CNRS, Inst Genom Fonct, UMR 5203, Montpellier, France

[2] INSERM, U1191, Montpellier, France

[3] Univ Montpellier, Montpellier, France

来源：

MUCOSAL IMMUNOLOGY | 2016年 / 9卷 / 06期

关键词：

STEM-CELLS; BRUSH CELLS; TRANSCRIPTION FACTOR; CHEMOSENSORY CELLS; GOBLET CELLS; DIFFERENTIATION; IDENTIFICATION; BITTER; CRYPT; LINEAGE;

D O I：

10.1038/mi.2016.68

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epithelial tuft cells (also known as "brush" cells in the airway) were first identified morphologically, almost six decades ago in the trachea and gastro-intestinal tract, but their function remained mysterious until three almost simultaneous reports recently revealed their essential role in the initiation of immune type 2 responses. This is a new and exciting example of cooperation between the epithelial and haematopoietic compartments for the management of enteric parasite infections. Here we review tuft cell functions and markers, and anchors epithelial tuft cells within the current paradigm of type 2 immune responses.

引用

页码：1353 / 1359

页数：7

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