Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811

被引:1
作者
Li, Shi Hui [1 ]
Dong, Wen Chuan [1 ]
Fan, Li [1 ]
Wang, Guang Sheng [1 ]
机构
[1] Aviat Gen Hosp, Dept Oncol, 3 Beiyuan Rd, Beijing 100012, Peoples R China
来源
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2016年 / 8卷 / 09期
关键词
Chronic lymphocytic leukemia; CXCR4; WZ811; docetaxel; BREAST-CANCER CELLS; CHEMOKINE RECEPTOR; IN-VITRO; GROWTH-FACTOR; MIGRATION; MICROENVIRONMENT; PROLIFERATION; EXPRESSION; APOPTOSIS; INVASION;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
CXCR4 is a chemokine and chemokine receptor pair playing critical roles in tumorigenesis. Overexpression of C-X-C chemokine receptor type 4 (CXCR4) is a hallmark of many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia and non-Hodgkin's lymphoma, and generally correlates with a poor prognosis. A highly potent competitive antagonist of CXCR4, WZ811, recently has been identified with suppression of cancer cells aggressive in a variety of cancers. However, the effects of WZ811 on chronic lymphocytic leukemia cells have not yet been defined. The effect of WZ811 on chronic lymphocytic leukemia cells TF-1 and UT-7 cells in proliferation, colony formation, and cell migration in vitro were measured respectively. Decreased in cell viability, colony formation, migration, and survival with cell cycle arrest and higher sensitivity to docetaxel in vitro was observed upon WZ811 treatment. In mouse xenograft models developed with human leukemia cells, WZ811 exhibited tumor growth inhibition. Collectively, we have demonstrated that CXCR4 inhibition by WZ811 has the potential for the treatment of human hematological malignancies. This study demonstrated that WZ811 may be a novel approach in the treatment of chronic lymphocytic leukemia.
引用
收藏
页码:3812 / 3821
页数:10
相关论文
共 50 条
[41]   CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression [J].
Sun, Xueqing ;
Cheng, Guangcun ;
Hao, Mingang ;
Zheng, Jianghua ;
Zhou, Xiaoming ;
Zhang, Jian ;
Taichman, Russell S. ;
Pienta, Kenneth J. ;
Wang, Jianhua .
CANCER AND METASTASIS REVIEWS, 2010, 29 (04) :709-722
[42]   Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma [J].
Barbieri, Federica ;
Bajetto, Adriana ;
Thellung, Stefano ;
Wuerth, Roberto ;
Florio, Tullio .
EXPERT OPINION ON DRUG DISCOVERY, 2016, 11 (11) :1093-1109
[43]   CXCR4 antagonists suppress small cell lung cancer progression [J].
Taromi, Sanaz ;
Kayser, Gian ;
Catusse, Julie ;
von Elverfeldt, Dominik ;
Reichardt, Wilfried ;
Braun, Friederike ;
Weber, Wolfgang A. ;
Zeiser, Robert ;
Burger, Meike .
ONCOTARGET, 2016, 7 (51) :85185-85195
[44]   Dasatinib Inhibits CXCR4 Signaling in Chronic Lymphocytic Leukaemia Cells and Impairs Migration Towards CXCL12 [J].
McCaig, Alison M. ;
Cosimo, Emilio ;
Leach, Michael T. ;
Michie, Alison M. .
PLOS ONE, 2012, 7 (11)
[45]   Cortactin, a Lyn substrate, is a checkpoint molecule at the intersection of BCR and CXCR4 signalling pathway in chronic lymphocytic leukaemia cells [J].
Martini, Veronica ;
Gattazzo, Cristina ;
Frezzato, Federica ;
Trimarco, Valentina ;
Pizzi, Marco ;
Chiodin, Giorgia ;
Severin, Filippo ;
Scomazzon, Edoardo ;
Guzzardo, Vincenza ;
Saraggi, Deborah ;
Raggi, Flavia ;
Martinello, Leonardo ;
Facco, Monica ;
Visentin, Andrea ;
Piazza, Francesco ;
Brunati, Anna Maria ;
Semenzato, Gianpietro ;
Trentin, Livio .
BRITISH JOURNAL OF HAEMATOLOGY, 2017, 178 (01) :81-93
[46]   Silencing of CXCR4 Blocks Progression of Ovarian Cancer and Depresses Canonical Wnt Signaling Pathway [J].
Wang, Jia ;
Cai, Jing ;
Han, Fang ;
Yang, Chun ;
Tong, Qiaoling ;
Cao, Ting ;
Wu, Liying ;
Wang, Zehua .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (06) :981-987
[47]   Role of CXCR4 in the progression and therapy of acute leukaemia [J].
Su, Long ;
Hu, Zheng ;
Yang, Yong-Guang .
CELL PROLIFERATION, 2021, 54 (07)
[48]   Double-Targeted Knockdown of miR-21 and CXCR4 Inhibits Malignant Glioma Progression by Suppression of the PI3K/AKT and Raf/MEK/ERK Pathways [J].
Liu, Feijiao ;
Yang, Bo .
BIOMED RESEARCH INTERNATIONAL, 2020, 2020
[49]   Progression of squamous cell carcinoma is regulated by miR-139-5p/CXCR4 [J].
Jiang, Qian ;
Cao, Yiting ;
Qiu, Yating ;
Li, Chenlin ;
Liu, Liu ;
Xu, Guangzhou .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2020, 25 :1732-1745
[50]   Suppression of the SDF-1/CXCR4/-catenin axis contributes to bladder cancer cell growth inhibition in vitro and in vivo [J].
Zhang, Tao ;
Yang, Fei ;
Li, Wenbiao ;
Liu, Bolong ;
Li, Wende ;
Chen, Zhiyi ;
Wang, Can .
ONCOLOGY REPORTS, 2018, 40 (03) :1666-1674