Process intensification in continuous flow biocatalysis by up and downstream processing strategies

被引：28
作者：
Meyer, Lars -Erik [1 ]
Hobisch, Markus [1 ]
Kara, Selin [1 ,2 ]
机构：
[1] Aarhus Univ, Dept Biol & Chem Engn, Biocatalysis & Bioproc Grp, Gustav Wieds Vej 10, DK-8000 Aarhus, Denmark
[2] Leibniz Univ Hannover, Inst Tech Chem, Callinstr 5, D-30167 Hannover, Germany
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2022年 / 78卷
关键词：
IMMOBILIZATION; RESOLUTION; AMINES;
D O I：
10.1016/j.copbio.2022.102835
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we focus on the holistic continuous enzymatic production and put special emphasis on process intensification by up- and downstream processing in continuous flow biocatalysis. After a brief introduction, we provide an overview of current examples of enzyme immobilization as an upstream process for flow biocatalysis. Thereafter, we provide an overview of unit operations as downstream processing strategies, namely continuous (i) liquid-liquid extraction, (ii) adsorptive downstream processing, and (iii) crystallization and precipitation. Eventually, we present our perspectives on future trends in this research field.
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页数：7
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