Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats

被引:14
|
作者
Roseman, Alexander S. [1 ]
McGregor, Claire [1 ]
Thornton, Janice E. [1 ]
机构
[1] Oberlin Coll, Dept Biol, Oberlin, OH 44074 USA
关键词
Phencyclidine; Novel object recognition; Estradiol; Schizophrenia; Cognitive deficits; Rat; DENDRITIC SPINE DENSITY; SPATIAL MEMORY; ANIMAL-MODELS; FEMALE MICE; ATYPICAL ANTIPSYCHOTICS; HORMONE REPLACEMENT; PREFRONTAL CORTEX; SCHIZOPHRENIA; ESTROGEN; WOMEN;
D O I
10.1016/j.bbr.2012.04.037
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Clinical studies have suggested that estrogens may affect the symptoms of schizophrenia. The novel object recognition task (NORT) in female rats treated with sub-chronic phencyclidine (PCP) was used as an animal model of the cognitive deficits in schizophrenia. The current studies investigated whether chronic estradiol (E) could alleviate sub-chronic PCP-induced cognitive deficits in the NORT. Adult Sprague-Dawley rats were ovariectomized (ovx) and treated with either sub-chronic PCP (2 mg/kg bidaily i.p. for seven days), or with 0.9% saline and their object recognition memory was tested with the NORT using an acquisition trial, 1 min inter-trial interval, and retention trial. Sub-chronic PCP administration did not reliably affect behavior in the acquisition trial but significantly impaired object recognition in the retention trial for 1-2 and 27-29 weeks. Ovx females spent significantly (p < 0.05) more time exploring the novel compared to the familiar object, whereas PCP-treated ovx females did not. This effect of PCP was attenuated by long-lasting E capsules implanted prior to PCP treatment. PCP-treated females implanted with E again spent significantly more time exploring the novel compared to the familiar object (p < 0.01). When ovx rats were treated with sub-chronic PCP and a long-lasting E capsule was implanted either before or after PCP treatment, estradiol alleviated the PCP-induced deficits when administered in either regimen (p = 0.01 and p = 0.047 respectively). These data suggest that further exploration of estradiol as a possible therapeutic compound to treat the cognitive deficits of schizophrenia is warranted. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:105 / 112
页数:8
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