The structure of glibenclamide in the solid state

被引：23

作者：

Sanz, Dionisia ^{[1
]}

Claramunt, Rosa M. ^{[1
]}

Alkorta, Ibon ^{[2
]}

Sanchez-Sanz, Goar ^{[2
]}

Elguero, Jose ^{[2
]}

机构：

[1] UNED, Fac Ciencias, Dept Quim Organ & Bioorgan, E-28040 Madrid, Spain

[2] CSIC, Inst Quim Med, E-28006 Madrid, Spain

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2012年 / 50卷 / 03期

关键词：

SSNMR; GIAO; B3LYP; 6-311++G(d; p); MAGNETIC-RESONANCE-SPECTROSCOPY; MOLECULAR-ORBITAL METHODS; C-13; NMR-SPECTRA; CHEMICAL-SHIFTS; DERIVATIVES; DRUG; TRANSFORMATION; POLYMORPHISM; TAUTOMERISM; IMPROVEMENT;

D O I：

10.1002/mrc.2868

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected. Copyright (C) 2012 John Wiley & Sons, Ltd.

引用

页码：246 / 255

页数：10

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