Treatment challenges in and outside a network setting: Gastrointestinal neuroendocrine tumours

Gastroenteropancreatic neuroendocrine tumours (GEP NETs) are relatively rare neoplasms arising from the enterochromaffin cells of the gastrointestinal tract. They comprise a heterogeneous group of tumours with a diverse natural history, variable biological behaviour and different clinical outcomes. Their management is often complex and may include a combination of surgery, systemic treatments and locoregional approaches. A multidisciplinary team approach is therefore essential for the optimal care of patients with GEP NETs. In this article, the authors review the role and structure of multidisciplinary care models, the importance of regional centres of expertise and institutional networks for the management of these rare neoplasms, as well as the multidisciplinary therapeutic challenges that NET clinicians are often faced with. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.