Chelation-Controlled Stereospecific Cross-Coupling Reaction between Alkenes for Atroposelective Synthesis of Axially Chiral Conjugated Dienes

被引：26

作者：

Dai, Dong-Ting ^{[1
]}

Yang, Meng-Wei ^{[1
]}

Chen, Zhi-Yuan ^{[1
]}

Wang, Zi-Lu ^{[1
]}

Xu, Yun-He ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; NATURAL-PRODUCTS; ATROPISOMERS; LIGANDS; CONSTRUCTION; BINOL; ACTIVATION; 1,3-DIENES; CATALYSIS; STYRENES;

D O I：

10.1021/acs.orglett.2c00386

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this protocol, an efficient palladium-catalyzed asymmetric synthesis of axially chiral conjugated dienes via alkenyl C-H olefination is reported. The corresponding atropisomeric styrenes containing a conjugated diene scaffold were obtained in good yields with good enantioselectivities. This synthetic strategy features an easy operation, mild reaction conditions, a wide functionality tolerance, and high efficiency.

引用

页码：1979 / 1984

页数：6

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